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. 2023 Feb 8;2(1):load006.

doi: 10.1093/lifemeta/load006. eCollection 2023 Feb.

You are what you eat: feeding neurons in nutrient regulation of behavior

Jessie C Morrill¹, Qingchun Tong²

Affiliations

Affiliations

¹ Department of Animal Science, University of Nebraska, Lincoln, Lincoln, NE 68503, USA.
² Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, McGovern Medical School of the University of Texas Health Science Center at Houston, TX 77030, USA.

PMID: 39872512
PMCID: PMC11749734
DOI: 10.1093/lifemeta/load006

You are what you eat: feeding neurons in nutrient regulation of behavior

Jessie C Morrill et al. Life Metab. 2023.

. 2023 Feb 8;2(1):load006.

doi: 10.1093/lifemeta/load006. eCollection 2023 Feb.

Authors

Jessie C Morrill¹, Qingchun Tong²

Affiliations

¹ Department of Animal Science, University of Nebraska, Lincoln, Lincoln, NE 68503, USA.
² Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, McGovern Medical School of the University of Texas Health Science Center at Houston, TX 77030, USA.

PMID: 39872512
PMCID: PMC11749734
DOI: 10.1093/lifemeta/load006

No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare that no conflict of interest exists.

Figures

Figure 1
Agouti-related protein (AgRP)-expressing neurons within the arcuate (ARC) hypothalamus sense nutrient availability; low circulating levels of essential amino acids (EAAS), including leucine, and low levels of glucose and leptin result in activation of AgRP neurons and subsequent promotion of feeding and reduction of depressive behaviors. Deprivation of leucine reduces depressive behaviors via a general control non-derepressible 2 (GCN2)-mediated mechanism in AgRP neurons. Illustration is created using Biorender.

See this image and copyright information in PMC

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