A biomarker framework for cardiac aging: the Aging Biomarker Consortium consensus statement

Aging Biomarker Consortium; Weiwei Zhang¹, Yang Che², Xiaoqiang Tang³, Siqi Chen^{4

5}, Moshi Song^{4

5

6

7}, Li Wang², Ai-Jun Sun^{8

9

10

11}, Hou-Zao Chen¹², Ming Xu^{13

14}, Miao Wang^{2

15}, Jun Pu¹⁶, Zijian Li^{13

17

18}, Junjie Xiao^{19

20}, Chun-Mei Cao^{21

22

23}, Yan Zhang^{24

25}, Yao Lu²⁶, Yingxin Zhao²⁷, Yan-Jiang Wang^{28

29

30

31}, Cuntai Zhang^{32

33}, Tao Shen³⁴, Weiqi Zhang^{5

7

35}, Ling Tao³⁶, Jing Qu^{5

6

7

37}, Yi-Da Tang³⁸, Guang-Hui Liu^{4

5

6

7

39}, Gang Pei⁴⁰, Jian Li³⁴, Feng Cao¹

Affiliations

¹ Department of Cardiology, The Second Medical Centre, Chinese PLA General Hospital, National Clinical Research Center for Geriatric Diseases, Beijing 100853, China.
² State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
³ Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University, Chengdu 610041, China.
⁴ State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
⁵ University of Chinese Academy of Sciences, Beijing 100049, China.
⁶ Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China.
⁷ Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China.
⁸ Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai 200433, China.
⁹ Key Laboratory of Viral Heart Diseases, National Health Commission, Shanghai 200433, China.
¹⁰ Key Laboratory of Viral Heart Diseases, Chinese Academy of Medical Sciences, Shanghai 200433, China.
¹¹ Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China.
¹² Department of Biochemistry and Molecular Biology, State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China.
¹³ Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, Beijing 100191, China.
¹⁴ NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing 100191, China.
¹⁵ Clinical Pharmacology Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
¹⁶ State Key Laboratory for Oncogenes and Related Genes, Department of Cardiology, Shanghai Jiao Tong University, Shanghai 200025, China.
¹⁷ Beijing Key Laboratory of Cardiovascular Receptors Research, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing 100191, China.
¹⁸ Department of Pharmacy, Peking University Third Hospital, Beijing 100191, China.
¹⁹ Shanghai Engineering Research Center of Organ Repair, School of Medicine, Shanghai University, Shanghai 200444, China.
²⁰ Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, School of Life Science, Shanghai University, Shanghai 200444, China.
²¹ Laboratory of Cardiovascular Science, Beijing Clinical Research Institute, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
²² Capital Institute of Pediatrics, Beijing 100020, China.
²³ Graduate School of Peking Union Medical College, Beijing 100730, China.
²⁴ State Key Laboratory of Membrane Biology, Institute of Molecular Medicine, College of Future Technology, Peking University, Beijing 100871, China.
²⁵ Institute of Cardiovascular Sciences and Key Laboratory of Molecular Cardiovascular Sciences, School of Basic Medical Sciences, Ministry of Education, Peking University Health Science Center, Beijing 100191, China.
²⁶ Clinical Research Center, The Third Xiangya Hospital, Central South University, Changsha 410013, China.
²⁷ Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing 100029, China.
²⁸ Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing 400042, China.
²⁹ Institute of Brain and Intelligence, Third Military Medical University, Chongqing 400042, China.
³⁰ Chongqing Key Laboratory of Ageing and Brain Diseases, Chongqing 400016, China.
³¹ Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China.
³² Gerontology Center of Hubei Province, Wuhan 430000, China.
³³ Institute of Gerontology, Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
³⁴ The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing 100730, China.
³⁵ CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China.
³⁶ Department of Cardiology, Xijing Hospital, the Fourth Military Medical University, Xi'an 710032, China.
³⁷ State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
³⁸ Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, Key Laboratory of Molecular Cardiovascular Sciences (Peking University), Ministry of Education, NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Key Laboratory of Cardiovascular Receptors Research, Beijing 100191, China.
³⁹ Advanced Innovation Center for Human Brain Protection, and National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing 100053, China.
⁴⁰ Shanghai Key Laboratory of Signaling and Disease Research, Laboratory of Receptor-Based Biomedicine, The Collaborative Innovation Center for Brain Science, School of Life Sciences and Technology, Tongji University, Shanghai 200070, China.

PMID: 39872891
PMCID: PMC11749273
DOI: 10.1093/lifemedi/lnad035

A biomarker framework for cardiac aging: the Aging Biomarker Consortium consensus statement

Aging Biomarker Consortium et al. Life Med. 2023.

. 2023 Sep 27;2(5):lnad035.

doi: 10.1093/lifemedi/lnad035. eCollection 2023 Oct.

Authors

Affiliations

¹ Department of Cardiology, The Second Medical Centre, Chinese PLA General Hospital, National Clinical Research Center for Geriatric Diseases, Beijing 100853, China.
² State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
³ Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University, Chengdu 610041, China.
⁴ State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
⁵ University of Chinese Academy of Sciences, Beijing 100049, China.
⁶ Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China.
⁷ Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China.
⁸ Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai 200433, China.
⁹ Key Laboratory of Viral Heart Diseases, National Health Commission, Shanghai 200433, China.
¹⁰ Key Laboratory of Viral Heart Diseases, Chinese Academy of Medical Sciences, Shanghai 200433, China.
¹¹ Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China.
¹² Department of Biochemistry and Molecular Biology, State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China.
¹³ Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, Beijing 100191, China.
¹⁴ NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing 100191, China.
¹⁵ Clinical Pharmacology Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
¹⁶ State Key Laboratory for Oncogenes and Related Genes, Department of Cardiology, Shanghai Jiao Tong University, Shanghai 200025, China.
¹⁷ Beijing Key Laboratory of Cardiovascular Receptors Research, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing 100191, China.
¹⁸ Department of Pharmacy, Peking University Third Hospital, Beijing 100191, China.
¹⁹ Shanghai Engineering Research Center of Organ Repair, School of Medicine, Shanghai University, Shanghai 200444, China.
²⁰ Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, School of Life Science, Shanghai University, Shanghai 200444, China.
²¹ Laboratory of Cardiovascular Science, Beijing Clinical Research Institute, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
²² Capital Institute of Pediatrics, Beijing 100020, China.
²³ Graduate School of Peking Union Medical College, Beijing 100730, China.
²⁴ State Key Laboratory of Membrane Biology, Institute of Molecular Medicine, College of Future Technology, Peking University, Beijing 100871, China.
²⁵ Institute of Cardiovascular Sciences and Key Laboratory of Molecular Cardiovascular Sciences, School of Basic Medical Sciences, Ministry of Education, Peking University Health Science Center, Beijing 100191, China.
²⁶ Clinical Research Center, The Third Xiangya Hospital, Central South University, Changsha 410013, China.
²⁷ Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing 100029, China.
²⁸ Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing 400042, China.
²⁹ Institute of Brain and Intelligence, Third Military Medical University, Chongqing 400042, China.
³⁰ Chongqing Key Laboratory of Ageing and Brain Diseases, Chongqing 400016, China.
³¹ Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China.
³² Gerontology Center of Hubei Province, Wuhan 430000, China.
³³ Institute of Gerontology, Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
³⁴ The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing 100730, China.
³⁵ CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China.
³⁶ Department of Cardiology, Xijing Hospital, the Fourth Military Medical University, Xi'an 710032, China.
³⁷ State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
³⁸ Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, Key Laboratory of Molecular Cardiovascular Sciences (Peking University), Ministry of Education, NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Key Laboratory of Cardiovascular Receptors Research, Beijing 100191, China.
³⁹ Advanced Innovation Center for Human Brain Protection, and National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing 100053, China.
⁴⁰ Shanghai Key Laboratory of Signaling and Disease Research, Laboratory of Receptor-Based Biomedicine, The Collaborative Innovation Center for Brain Science, School of Life Sciences and Technology, Tongji University, Shanghai 200070, China.

PMID: 39872891
PMCID: PMC11749273
DOI: 10.1093/lifemedi/lnad035

Abstract

Cardiac aging constitutes a significant risk factor for cardiovascular diseases prevalent among the elderly population. Urgent attention is required to prioritize preventive and management strategies for age-related cardiovascular conditions to safeguard the well-being of elderly individuals. In response to this critical challenge, the Aging Biomarker Consortium (ABC) of China has formulated an expert consensus on cardiac aging biomarkers. This consensus draws upon the latest scientific literature and clinical expertise to provide a comprehensive assessment of biomarkers associated with cardiac aging. Furthermore, it presents a standardized methodology for characterizing biomarkers across three dimensions: functional, structural, and humoral. The functional dimension encompasses a broad spectrum of markers that reflect diastolic and systolic functions, sinus node pacing, neuroendocrine secretion, coronary microcirculation, and cardiac metabolism. The structural domain emphasizes imaging markers relevant to concentric cardiac remodeling, coronary artery calcification, and epicardial fat deposition. The humoral aspect underscores various systemic (N) and heart-specific (X) markers, including endocrine hormones, cytokines, and other plasma metabolites. The ABC's primary objective is to establish a robust foundation for assessing cardiac aging, thereby furnishing a dependable reference for clinical applications and future research endeavors. This aims to contribute significantly to the enhancement of cardiovascular health and overall well-being among elderly individuals.

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Conflict of interest statement

All authors declare no competing interests. Guang-Hui Liu holds the position of Editor-in-Chief and is blinded from peer review and the decision making for the manuscript. The figure is created with BioRender.com.

Figures

**Figure 1.**
**Biomarker framework for cardiac aging.** The proposed framework for assessing cardiac aging comprises three dimensions: functional, structural, and humoral biomarkers. The most strongly recommended cardiac aging biomarkers, highlighted in red, encompass a wide range of changes occurring at various levels within the heart during the aging process. These biomarkers hold the potential for widespread utilization in routine clinical practice. However, it is essential to emphasize that further validation is required to assess their effectiveness in evaluating biological cardiac aging. Abbreviations: Echo, echocardiography; CMR, cardiac magnetic resonance imaging; ECG, electrocardiograph; SPECT, single photon emission computed tomography; ELISA, enzyme-linked immunosorbent assay; PET, positron emission tomography; CT, computed tomography; CCTA, coronary computed tomography angiography; Ang II, angiotensin II; PTH, parathyroid hormone; T3, triiodothyronine; T4, thyroxine; TSH, thyroid stimulating hormone; IL-1β, interleukin-1β; IL-6, interleukin-6; hs-CRP, high-sensitivity C-reactive protein; TMAO, trimethylamine N-oxide; NT-proBNP, N-terminal pro-B-type natriuretic peptide; hs-TnT, hypersensitive troponin T.

See this image and copyright information in PMC

References

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A biomarker framework for cardiac aging: the Aging Biomarker Consortium consensus statement

Affiliations

A biomarker framework for cardiac aging: the Aging Biomarker Consortium consensus statement

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

References

LinkOut - more resources

Full Text Sources