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. 2024 Jun 22;3(6):loae027.
doi: 10.1093/lifemeta/loae027. eCollection 2024 Dec.

The FTO variant conferring enhanced UCP1 expression is linked to human migration out of Africa

Nan Yin  1   2 , Dan Zhang  3 , Jiqiu Wang  1   2
Affiliations

The FTO variant conferring enhanced UCP1 expression is linked to human migration out of Africa

Nan Yin et al. Life Metab. .
No abstract available

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Conflict of interest statement

The authors declare that no conflict of interest exists.

Figures

Figure 1
Figure 1
The FTO rs1421085 T>C variant enhances UCP1 expression and traces human migration out of Africa. (a) The representative immunofluorescence images of UCP1 (red) in human fetal brown fat, in which the nuclei are stained with 4ʹ-6-diamidino-2-phenylindole (DAPI) (blue) and lipid droplets with Perilipin 1 (PLIN1) (green) (scale bar = 100 μm for the top 3 lines, and scale bar = 25 μm for the bottom enlarged panels). (b) Quantification analysis of UCP1 protein. For each BAT sample, four visual fields were randomly selected for fluorescence intensity quantification, and the average values were used for statistical analysis. A total of 3:3 samples were included in the analysis. (c) The mRNA expression level of UCP1 in the two genotypes. A total of 45 samples (35 in the TT-alleles and 10 in the TC-alleles) were included in the analysis. (d and e) Correlation analysis of the frequency of the rs1421085_C variant and mean earth skin temperature in January (d) or absolute latitude (e). The icons of panel d and e were provided by BioRender. (f) The migration route of modern humans together with a genetic diffusion pattern of the rs1421085 T>C variant on the African and the Eurasian continents. (The work of Nielsen et al. [9] was adapted to label the migration route time). Each circle represents a distinct population, circle size indicates the frequency of rs1421085_C allele, and map color represents the mean earth skin temperature in January. Arrows indicate the directions of population migration.
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