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. 2025 Jan;20(1):335-341.
doi: 10.1016/j.jds.2024.06.020. Epub 2024 Jul 12.

COVID-19 vaccination patterns among oral cancer patients: A comprehensive analysis in a medical center in Taiwan

Chi-Sheng Cheng  1 , Han-Pang Liu  1   2 , Li-Tzu Lee  1
Affiliations

COVID-19 vaccination patterns among oral cancer patients: A comprehensive analysis in a medical center in Taiwan

Chi-Sheng Cheng et al. J Dent Sci. 2025 Jan.

Abstract

Background/purpose: COVID-19 vaccines are supplied at no-cost to residents as a measure to prevent comorbidities, fatalities, and the increased risk of community transmission, thus protecting public health systems. However, vaccine acceptance among cancer patients remained uncertain. This study aimed to elucidate the vaccination rates among oral cancer patients at a medical center in Taiwan.

Materials and methods: We included Individuals who attended for routine follow-ups from January 2021 to December 2022, with a total of 1448 patients subjected to comprehensive analysis. Medical records were reviewed to identify factors influencing vaccine acceptance.

Results: Our findings indicate that 1,264 patients received vaccinations, while 184 remained unvaccinated. The vaccination rates among patients in advanced disease stages and those with neck lymph node metastasis (N+) were significantly lower (both P < 0.001). Furthermore, a notable lower vaccination rate was evident among patients receiving active treatment modalities (P < 0.01). Conversely, age, and comorbidities (evaluated using the New Charlson Comorbidity Index), didn't show a significant correlation with vaccination rates. The risk of death caused by oral cancer among vaccinated patients was significantly lower compared to non-vaccinated group (P < 0.001). Logistic regression showed the risk of COVID infection was significant lower in vaccinated group than non-vaccinated group (OR = 0.31, P = 0.034).

Conclusion: The risk of COVID-19 infection in oral cancer patients was lower among vaccinated group, and the vaccination was not associated with more mortality. Identifying the characteristics of non-vaccinated individuals and understanding factors influencing vaccine hesitancy in oral cancer patients is vital for developing targeted strategies to improve vaccine uptake.

Keywords: COVID-19; Oral cancer patients; Public health strategies; Taiwan; Vaccination; Vaccine acceptance.

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Conflict of interest statement

The authors have no conflicts of interest relevant to this article.

Figures

Figure 1
Figure 1
COVID-19 vaccination by weeks (2021–2022).
Figure 2
Figure 2
Status of COVID-19 vaccination in oral cancer patients.
Figure 3
Figure 3
Types and percentages of COVID-19 vaccination in oral cancer patients. AZ, Oxford-AstraZeneca; BNT, Pfizer–BioNTech; M, Medigen.
See this image and copyright information in PMC

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References

    1. Fan V.Y., Cash R., Bertozzi S., Pate M. The when is less important than the what: an epidemic scale as an alternative to the WHO's public health emergency of international concern. Lancet Global Health. 2023;11:e1499–e1500. - PubMed
    1. Alquraan L., Alzoubi K.H., Rababa'h S.Y. Mutations of SARS-CoV-2 and their impact on disease diagnosis and severity. Inform Med Unlocked. 2023;39 - PMC - PubMed
    1. Rahman M.M., Masum M.H.U., Wajed S., Talukder A. A comprehensive review on COVID-19 vaccines: development, effectiveness, adverse effects, distribution and challenges. Virusdisease. 2022;33:1–22. - PMC - PubMed
    1. Gong I.Y., Vijenthira A., Powis M., et al. Association of COVID-19 vaccination with breakthrough infections and complications in patients with cancer. JAMA Oncol. 2023;9:386–394. - PMC - PubMed
    1. Rajan S., Akhtar N., Sharma S., Chakrabarti D., Kumar V. COVID-19 vaccination for cancer patients: evidence, priority, and practice. Vaccine. 2021;39:5075–5077. - PMC - PubMed

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