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. 2025 Jan 1;26(1):153-159.
doi: 10.31557/APJCP.2025.26.1.153.

Interleukin-17A and Interleukin-17F Gene Polymorphisms in Egyptian Patients with Chronic Hepatitis C and Hepatocellular Carcinoma

Ehab Mabrouk Abd El-Maksoud  1 , Noha El-Sayed Ibrahim  2 , Mohamed Mansour Saad Farag  3 , Menha Swellam  4
Affiliations

Interleukin-17A and Interleukin-17F Gene Polymorphisms in Egyptian Patients with Chronic Hepatitis C and Hepatocellular Carcinoma

Ehab Mabrouk Abd El-Maksoud et al. Asian Pac J Cancer Prev. .

Abstract

Objective: Interleukin IL-17A and IL-17F are critical cytokines involved in inflammatory processes. Genetic variations in IL-17A and IL-17F might be linked to chronic hepatitis C (CHC) and an increased risk of hepatocellular carcinoma (HCC), a cancer associated with long-term inflammation. This study aims to examine the relationship between specific polymorphisms in IL-17A (rs2275913) and IL-17F (rs763780) and their association with HCV-related HCC in an Egyptian population.

Methods: Authors conducted a case-control study involving 52 patients with chronic hepatitis C, 49 patients with HCV-related HCC, and 51 healthy controls. The study assessed the connection between the IL-17A rs2275913 and IL-17F rs763780 polymorphisms and chronic hepatitis C patients. Genotyping was performed using real-time PCR with TaqMan MGB-probe allelic discrimination.

Results: No significant differences in genotype and allele frequencies for IL-17A rs2275913 and IL-17F rs763780 were observed between CHC or HCC patients and control subjects. However, significant associations were found indicating an increased risk of HCC linked to CHC: the GG genotype of IL-17A rs2275913 in a recessive model (P = 0.0129); and CT and CT + CC genotypes as well as the C allele of IL-17F rs763780 (P = 0.0038, P = 0.0055 and P = 0.0277, respectively).

Conclusion: The study identifies a significant association between IL-17F rs763780 polymorphisms and a higher risk of HCC in Egyptian patients with chronic hepatitis C. No significant correlation was found between the IL-17A rs2275913 polymorphism and either chronic hepatitis C or HCC.

Keywords: Haplotype; Hepatocellular carcinoma; Interleukin-17; Polymorphism.

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Conflict of interest statement

The authors declare no conflicts of interest.

References

    1. Nomair AM, Kandil LS, Nomeir HM, Kandil NS. TGF-Β1 & PNPLA3 Genetic Variants and the Risk of Hepatic Fibrosis and HCC in Egyptian Patients with HCV-Related Liver Cirrhosis. Asian Pac J Cancer Prev. 2021;22(10):3317–3326. - PMC - PubMed
    1. Omran MH, Fotouh BE, Youssef SS, Ibrahim NE, Nabil W, Mahdy el-SM, et al. Association between low molecular polypeptide 7 single nucleotide polymorphism and response to therapy in hepatitis C virus infection. World J Hepatol. 2013;5(3):97–103. - PMC - PubMed
    1. Elbahrawy A, Ibrahim MK, Eliwa A, Alboraie M, Madian A, Aly HH. Current situation of viral hepatitis in Egypt. Microbiol Immunol. 2021;65(9):352–372. - PubMed
    1. Swellam M, Mahmoud MS, Ali AA. Diagnosis of hepatitis C virus infection by enzyme-linked immunosorbent assay and reverse transcriptase-nested polymerase chain reaction: a comparative evaluation. IUBMB Life. 2011;63(6):430–4. - PubMed
    1. Mostafa A, Ibrahim NE-S, Sabry D, Fathy W, Elkazaz AY. Insulin-like Growth Factor Initiates Hepatocellular Carcinoma in Chronic Hepatitis C Virus Patients through Induction of Long Non-coding Ribonucleic Acids AF085935: Role of LncRNA AF085935 in HCC development. Open Access Maced J Med Sci. 2021;9(A):222–8.

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