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. 1985 Jan 31;59(1):77-80.
doi: 10.1007/BF00162013.

Effect of acetazolamide (Diamox) on tear secretion

E J van Agtmaal, L Thörig, N J van Haeringen

Effect of acetazolamide (Diamox) on tear secretion

E J van Agtmaal et al. Doc Ophthalmol. .

Abstract

The side effects of acetazolamide (Diamox) on lacrimation were measured in rats by means of the cotton-thread tear test. After a daily oral 1-mg dose (administered for five days), comparable to the dose used for adult humans on a drug-to-bodyweight basis, tear production remained unaffected but the lacrimal peroxidase secretion decreased by 60% of the baseline level. After withdrawal of acetazolamide the peroxidase secretion returned to the baseline level.

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