Malignant adenomyoepithelioma after breast cancer with multiple local recurrences

Abstract

Malignant adenomyoepithelioma of the breast is a rare and challenging tumor in terms of diagnosis and treatment. It is exceptional to find this condition in a patient who has had breast cancer treated with breast-conserving surgery and radiotherapy. We present the case of a 46-year-old female patient with a history of invasive lobular carcinoma of the breast, who presented one year later with a malignant adenomyoepithelioma in the same breast, which recurred three times, despite undergoing various surgical treatments and even adjuvant chemotherapy regimen. The limited evidence and lack of consensus in the management of this type of tumor highlight the importance of a multidisciplinary approach. Upon reviewing the literature, we observed extensive heterogeneity in treatments and the lack of a gold standard. We believe that surgery is the cornerstone of treatment, and that both chemotherapy and radiotherapy may have a benefit that is still unknown.

Keywords: Adenomioepitelioma; Adenomyoepithelioma; Breast; Breast cancer; Chemotherapy; Cáncer de mama; Mama; Quimioterapia; Radioterapia; Radiotherapy.