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Review
. 2025 Mar;52(1):51-66.
doi: 10.1016/j.ogc.2024.10.002. Epub 2024 Nov 16.

Mental Well-being in Menopause

Robin Green  1 , Christina A Metcalf  2 , Nanette Santoro  3
Affiliations
Review

Mental Well-being in Menopause

Robin Green et al. Obstet Gynecol Clin North Am. 2025 Mar.

Abstract

The hormonal changes that accompany the transition to menopause are disruptive to most women, and for some, mental health maybe adversely affected. Depressive symptoms and major depression are the best-studied conditions in association with menopause, but anxiety, executive function, and comorbid pre-existing psychiatric conditions all influence the symptomatology that women will experience during this phase of their lives. The epidemiology, diagnosis, and evidence-based treatment guidelines for perimenopausal patients are discussed.

Keywords: Anxiety; Depression; Menopausal transition; Menopause; Mental health; Mood.

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Conflict of interest statement

Disclosure N. Santoro is a consultant to Ansh Labs, and a member of the Scientific Advisory Board for Astellas, Menogenix, and Amazon (Project Ember).