Microneedle patches: the next frontier in cardiovascular care

Abstract

Myocardial infarction is a condition where the heart muscle is damaged due to clogged coronary arteries. There are limited treatment options for treating myocardial infarction. Microneedle patches have recently become popular as a possibly viable therapy for myocardial. By adhering to the surface of the heart, these microneedle patches provide mechanical support, regenerative medicines, or cells directly to the injured tissue allowing for targeted treatment. These microneedle patches resolve the drawbacks of systemic therapy by facilitating targeted administration and integration with the goal of restoring damaged heart function. Recent advances in fabrication methods and current perspectives on the therapeutic advantages of cardiac microneedles patches used in the treatment of myocardial infarction are summarized in this review. Although the data is less in this area this review provides an avenue for the formulation scientist working in biomedical science to develop such microneedle patches for clinical applications in cardiology.

Keywords: Induced pluripotent stem cells (iPSCs); Mesenchymal stem cells (MSCs); Microneedles (MNs); Microneedles patch consisting of cardiac stromal cells (MNs-CSCs); Skeletal myoblasts (SMs); Synthetic cardiac stromal cells (synCSCs).