Author Correction: In vivo base editing extends lifespan of a humanized mouse model of prion disease

Meirui An^#^{1

2

3}, Jessie R Davis^#^{1

2

3}, Jonathan M Levy^{1

2

3}, Fiona E Serack⁴, John W Harvey⁴, Pamela P Brauer⁴, Catherine P Pirtle⁴, Kiara N Berríos^{1

2

3}, Gregory A Newby^{1

2

3}, Wei-Hsi Yeh^{1

2

3}, Nikita Kamath⁴, Meredith Mortberg⁴, Yuan Lian⁴, Michael Howard⁵, Kendrick DeSouza-Lenz⁵, Kenia Guzman⁵, Aaron Thai⁵, Samantha Graffam⁵, Vanessa Laversenne⁴, Alissa A Coffey⁴, Jeannine Frei⁴, Sarah E Pierce^{1

2

3}, Jiri G Safar⁶, Benjamin E Deverman⁴, Eric Vallabh Minikel^{7

8

9

10}, Sonia M Vallabh^{11

12

13

14}, David R Liu^{15

16

17}

Affiliations

¹ Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
² Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
³ Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA.
⁴ Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
⁵ Comparative Medicine, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
⁶ Case Western Reserve University, Cleveland, OH, USA.
⁷ Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA. eminikel@broadinstitute.org.
⁸ McCance Center for Brain Health and Department of Neurology, Massachusetts General Hospital, Boston, MA, USA. eminikel@broadinstitute.org.
⁹ Department of Neurology, Harvard Medical School, Boston, MA, USA. eminikel@broadinstitute.org.
¹⁰ Prion Alliance, Cambridge, MA, USA. eminikel@broadinstitute.org.
¹¹ Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA. svallabh@broadinstitute.org.
¹² McCance Center for Brain Health and Department of Neurology, Massachusetts General Hospital, Boston, MA, USA. svallabh@broadinstitute.org.
¹³ Department of Neurology, Harvard Medical School, Boston, MA, USA. svallabh@broadinstitute.org.
¹⁴ Prion Alliance, Cambridge, MA, USA. svallabh@broadinstitute.org.
¹⁵ Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of MIT and Harvard, Cambridge, MA, USA. drliu@fas.harvard.edu.
¹⁶ Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA. drliu@fas.harvard.edu.
¹⁷ Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA. drliu@fas.harvard.edu.

^# Contributed equally.

PMID: 39885360
PMCID: PMC12003190
DOI: 10.1038/s41591-025-03540-x

Published Erratum

Author Correction: In vivo base editing extends lifespan of a humanized mouse model of prion disease

Meirui An et al. Nat Med. 2025 Apr.

. 2025 Apr;31(4):1369.

doi: 10.1038/s41591-025-03540-x.

Authors

Affiliations

¹ Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
² Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
³ Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA.
⁴ Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
⁵ Comparative Medicine, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
⁶ Case Western Reserve University, Cleveland, OH, USA.
⁷ Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA. eminikel@broadinstitute.org.
⁸ McCance Center for Brain Health and Department of Neurology, Massachusetts General Hospital, Boston, MA, USA. eminikel@broadinstitute.org.
⁹ Department of Neurology, Harvard Medical School, Boston, MA, USA. eminikel@broadinstitute.org.
¹⁰ Prion Alliance, Cambridge, MA, USA. eminikel@broadinstitute.org.
¹¹ Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA. svallabh@broadinstitute.org.
¹² McCance Center for Brain Health and Department of Neurology, Massachusetts General Hospital, Boston, MA, USA. svallabh@broadinstitute.org.
¹³ Department of Neurology, Harvard Medical School, Boston, MA, USA. svallabh@broadinstitute.org.
¹⁴ Prion Alliance, Cambridge, MA, USA. svallabh@broadinstitute.org.
¹⁵ Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of MIT and Harvard, Cambridge, MA, USA. drliu@fas.harvard.edu.
¹⁶ Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA. drliu@fas.harvard.edu.
¹⁷ Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA. drliu@fas.harvard.edu.

^# Contributed equally.

PMID: 39885360
PMCID: PMC12003190
DOI: 10.1038/s41591-025-03540-x

No abstract available

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Erratum for

In vivo base editing extends lifespan of a humanized mouse model of prion disease.
An M, Davis JR, Levy JM, Serack FE, Harvey JW, Brauer PP, Pirtle CP, Berríos KN, Newby GA, Yeh WH, Kamath N, Mortberg M, Lian Y, Howard M, DeSouza-Lenz K, Guzman K, Thai A, Graffam S, Laversenne V, Coffey AA, Frei J, Pierce SE, Safar JG, Deverman BE, Minikel EV, Vallabh SM, Liu DR. An M, et al. Nat Med. 2025 Apr;31(4):1319-1328. doi: 10.1038/s41591-024-03466-w. Epub 2025 Jan 14. Nat Med. 2025. PMID: 39810005 Free PMC article.

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Author Correction: In vivo base editing extends lifespan of a humanized mouse model of prion disease

Affiliations

Author Correction: In vivo base editing extends lifespan of a humanized mouse model of prion disease

Authors

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