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. 2025 Jan;22(1):57-65.
doi: 10.30773/pi.2024.0222. Epub 2025 Jan 15.

Diabetes Is Positively Associated With High Risk of Depression in Korean Cervical Cancer Patients: Korean National Health and Nutrition Examination Survey 2010-2021

Seon-Mi Lee  1   2 , Daun Shin  3 , Aeran Seol  1 , Sanghoon Lee  1 , Hyun-Woong Cho  4 , Kyung-Jin Min  5 , Jin-Hwa Hong  4 , Jae-Kwan Lee  4 , Nak-Woo Lee  5 , Jae-Yun Song  1 , Won Jun Choi  2
Affiliations

Diabetes Is Positively Associated With High Risk of Depression in Korean Cervical Cancer Patients: Korean National Health and Nutrition Examination Survey 2010-2021

Seon-Mi Lee et al. Psychiatry Investig. 2025 Jan.

Abstract

Objective: Objective of this study is to evaluate the association between high risk of depression and metabolic diseases such as hypertension, diabetes, and dyslipidemia in Korean cervical cancer patients.

Methods: A total of 330 women with cervical cancer were included in this study, using data from the Korea National Health and Nutrition Examination Survey from 2010 to 2021. Participants were categorized into two groups-high risk of depression and non-depression-based on their answers to survey items related to depression. A multivariate logistic regression analysis was used to evaluate the influence of metabolic diseases on high risk of depression in patients with cervical cancer.

Results: A total of 78 (23.64%) and 252 (76.36%) women were classified into the high risk of depression and non-depression groups, respectively. In multivariate logistic regression analysis adjusting for age, menopausal status, and smoking status, diabetes was associated with an odds ratio of 2.47 (95% confidence interval: 1.205, 5.071) for high risk of depression in cervical cancer patients. However, among the metabolic diseases, hypertension, and dyslipidemia were not associated with high risk of depression in patients with cervical cancer.

Conclusion: This study suggests that diabetes may be associated with a increased risk of high risk of depression in cervical cancer patients. Therefore, appropriate treatment of diabetes in cervical cancer patients may contribute to lowering the risk of depression in the future.

Keywords: Cervical cancer; Depression; Diabetes mellitus; Gynecological cancer; High risk of depression.

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Conflict of interest statement

Conflicts of Interest

The authors have no potential conflicts of interest to disclose.

Figures

Figure 1.
Figure 1.
Diagram of participants included in the final analysis. KNHANES, Korea National Health and Nutrition Examination Survey.
Figure 2.
Figure 2.
Forest plot graph of multivariate logistic regression analysis of the risk for high risk of depression by metabolic diseases status such as hypertension, diabetes, and dyslipidemia.
Figure 3.
Figure 3.
Schematic representation of the mechanism between diabetes and depressive behaviors. ROS, reactive oxygen species; MAO, monoamine oxidases; NE, norepinephrine.
See this image and copyright information in PMC

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