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. 2025 Jan 16:14:1472765.
doi: 10.3389/fcimb.2024.1472765. eCollection 2024.

Identifying key blood markers for bacteremia in elderly patients: insights into bacterial pathogens

Shi-Yan Zhang  1 , Ying Zhuo  1 , Bu-Ren Li  1 , Ying-Ying Jiang  1 , Jie Zhang  1 , Na Cai  1 , Lin Yang  1
Affiliations

Identifying key blood markers for bacteremia in elderly patients: insights into bacterial pathogens

Shi-Yan Zhang et al. Front Cell Infect Microbiol. .

Abstract

Background: This study aimed to assess the distribution of bacteremia pathogens in elderly patients, examine the impact of gender on pathogen distribution, and evaluate the predictive value of routine blood parameters for diagnosing bacteremia.

Methods: A retrospective analysis was conducted on 151 elderly patients (≥60 years old) admitted to Fuding Hospital, Fujian University of Traditional Chinese Medicine between October 2022 and June 2023. Comprehensive routine blood tests and blood cultures were performed. The diagnostic efficacy of routine blood parameters, including white blood cell (WBC), neutrophil-to-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and red blood cell distribution width (RDW), was evaluated using receive operating characteristic (ROC) curve analysis. Patients were categorized into either the culture-positive group (82 cases) or the culture-negative group (69 cases) according to blood culture results.

Results: No significant differences in age and gender were found between the culture-positive and culture-negative groups. The primary bacterial pathogens of bacteremia in the elderly were Escherichia coli, Klebsiella pneumoniae and Streptococcus. Elderly female patients demonstrated a significantly higher culture positivity rate for E. coli compared to their male counterparts (P = 0.021). The areas under the ROC curve (AUC) for the four parameters were as follows: WBC, 0.851 (95% confidence interval (CI) 0.790 - 0.912); NLR, 0.919 (95% CI 0.875 - 0.963); PLR, 0.609 (95% CI 0.518 - 0.700); and RDW was 0.626 (95% CI 0.563 - 0.717).

Conclusions: E. coli was identified as the predominant pathogenic microorganism causing bacteremia in the elderly, with a significantly higher culture positivity rate among female patients. Routine blood parameters (WBC, NLR, PLR, and RDW) demonstrated a predictive potential for diagnosing bacteremia in elderly patients.

Keywords: Escherichia coli; ROC analysis; bacteremia; blood culture; elderly; neutrophil-to-lymphocyte ratio.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Distribution of bacterial pathogens in elderly patients with bacteremia. Escherichia coli was the most prevalent pathogen (51.2%), followed by Klebsiella pneumoniae (18.3%), Streptococcus (12.2%), and others (18.3%).
Figure 2
Figure 2
Receiver operating characteristic (ROC) curves for blood parameters. The area under the curve (AUC) values were: White blood cell (WBC): 0.851; Neutrophil-to-lymphocyte ratio (NLR): 0.919; Platelet-to-lymphocyte ratio (PLR): 0.609; Red blood cell distribution width (RDW): 0.626. Optimal cutoff values, sensitivity, and specificity derived from the ROC analysis highlight the diagnostic performance of each parameter.
See this image and copyright information in PMC

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