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. 2025 Mar 3;157(2):e202413722.
doi: 10.1085/jgp.202413722. Epub 2025 Jan 31.

Modeling cardiac contractile cooperativity across species

Matthew Carter Childers  1
Affiliations

Modeling cardiac contractile cooperativity across species

Matthew Carter Childers. J Gen Physiol. .

Abstract

Phan and Fitzsimons (https://doi.org/10.1085/jgp.202413582) develop a new mathematical model of muscle contraction that explores cooperative mechanisms in small (murine) and large (porcine) myocardium.

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Conflict of interest statement

Disclosures: The author declares no competing interests exist.

Comment on

  • doi: 10.1085/jgp.202413582

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References

    1. Barefield, D.Y., Tonino P., Woulfe K.C., Rahmanseresht S., O’Leary T.S., Burnham H.V., Wasserstrom J.A., Kirk J.A., Previs M.J., Granzier H.L., and McNally E.M.. 2023. Myosin-binding protein H-like regulates myosin-binding protein distribution and function in atrial cardiomyocytes. Proc. Natl. Acad. Sci. USA. 120:e2314920120. 10.1073/pnas.2314920120 - DOI - PMC - PubMed
    1. Bremel, R.D., and Weber A.. 1972. Cooperation within actin filament in vertebrate skeletal muscle. Nat. New Biol. 238:97–101. 10.1038/newbio238097a0 - DOI - PubMed
    1. Brenner, B. 1986. The cross-bridge cycle in muscle. Mechanical, biochemical, and structural studies on single skinned rabbit psoas fibers to characterize cross-bridge kinetics in muscle for correlation with the actomyosin-ATPase in solution. Basic Res. Cardiol. 81:1–15. 10.1007/978-3-662-11374-5_1 - DOI - PubMed
    1. Brenner, B. 1988. Effect of Ca2+ on cross-bridge turnover kinetics in skinned single rabbit psoas fibers: Implications for regulation of muscle contraction. Proc. Natl. Acad. Sci. USA. 85:3265–3269. 10.1073/pnas.85.9.3265 - DOI - PMC - PubMed
    1. Campbell, K.S. 2009. Interactions between connected half-sarcomeres produce emergent mechanical behavior in a mathematical model of muscle. PLoS Comput. Biol. 5:e1000560. 10.1371/journal.pcbi.1000560 - DOI - PMC - PubMed

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