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Review
. 2025 Mar 1;19(1):59-64.
doi: 10.1097/SPC.0000000000000743. Epub 2025 Jan 30.

Buprenorphine: an old dog with new tricks

Ai Deen Ng  1 , Andrew Dickman  2
Affiliations
Review

Buprenorphine: an old dog with new tricks

Ai Deen Ng et al. Curr Opin Support Palliat Care. .

Abstract

Purpose of review: The survival rate of patients with a cancer or palliative care diagnosis has improved over the years although pain remains a debilitating symptom that many patients still require treatment with opioids. Compared to full mu-opioid receptor agonists such as morphine and oxycodone, buprenorphine continues to remain a second- or third-line choice in this group of patients.We have reviewed the pharmacology and clinical utility of buprenorphine to stimulate debate around the first-line use of buprenorphine in the management of pain in cancer patients.

Recent findings: Buprenorphine has a pharmacological profile that is unique and unlike any other opioid. It is associated with many immediate and long-term benefits, with lower risks of adverse effects that make it an ideal first-line choice in the management of cancer pain.

Summary: Buprenorphine appears to be a promising choice of opioid for cancer patients. Studies have found that buprenorphine is a safe and effective choice for many patients, making it a suitable first-line option for the management of cancer pain.

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References

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