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. 2025 Jan 31;20(1):e0316001.
doi: 10.1371/journal.pone.0316001. eCollection 2025.

A prospective model of the potential clinical and economic impact of cervical cancer screening supported by a mobile phone app

Fredrick Chite Asirwa  1 , Brian W Bresnahan  2   3 , Faith Yego  4 , Dana Duncan  5 , James K Karichu  6 , Louis P Garrison Jr  3   7
Affiliations

A prospective model of the potential clinical and economic impact of cervical cancer screening supported by a mobile phone app

Fredrick Chite Asirwa et al. PLoS One. .

Abstract

Introduction: Cervical cancer is a preventable and highly curable disease when detected early and adequately treated, yet it remains the leading cause of cancer-related death in women in Kenya due to low screening coverage and treatment. Implementing World Health Organization screening guidelines for human papillomavirus (HPV) is challenging due to the complex logistics of result return and follow-up requiring multiple clinic visits. Increasing the use of mobile technology can support follow-up care in cervical cancer screening programs.

Methods: We developed a prospective clinico-economic model to assess the potential impact of a mobile phone-based application ("app") communicating laboratory results and recommendations to improve follow-up care for cervical cancer screening in Kenya. The model is structured to simulate a three-visit pathway for HPV-based screening used in a clinical trial of the app and based on epidemiological data, clinical guideline-based workflow, and patient-based behavioral pathways. Published literature, expert elicitation, and time-and-motion observations were used to estimate clinical data, care pathways, and visit-related costs. This analysis was conducted from a base-case healthcare system perspective with a scenario from a "limited" societal perspective.

Results: In a simulated cohort of women using the app-based intervention compared to conventional care, with 10,000 women in each arm, use of the app is projected to increase healthcare costs by $12.53 per enrolled woman during the trial period and to detect and treat an additional 247 women-229 with precancerous cervical lesions and 18 with cervical cancer. The incremental cost-effectiveness ratio of the app versus conventional care was $174 per case detected and treated. This would be cost-saving given the average lifetime cost per cervical cancer case of $1,000-$3,000.

Conclusion: Use of a mobile phone-based app is costlier than conventional screening but by improving visit compliance, it can be a cost-effective and cost-saving strategy to enhance detection and treatment in cervical cancer screening programs.

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Conflict of interest statement

We have read the journal’s policy on competing interests, and the authors of this manuscript have the following competing interests: FCA, BWB, LPG, FY received research support from Roche Diagnostics. DD and JKK are employees of Roche Diagnostics.

Figures

Fig 1
Fig 1. Clinical trial workflow protocol.
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