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. 2025 Feb 1;107-B(2):246-252.
doi: 10.1302/0301-620X.107B2.BJJ-2024-0643.R1.

Identifying consensus and areas for future research in chondrosarcoma : a report from the Birmingham Orthopaedic Oncology Meeting

Lee M Jeys  1 , Guy V Morris  1 , Vineet J Kurisunkal  1 , Eduardo Botello  2 , Richard A Boyle  3 , Walid Ebeid  4 , Matthew T Houdek  5 , Ajay Puri  6 , Pietro Ruggieri  7 , Bernadette Brennan  8 ; BOOM Consensus Meeting Participants; Minna K Laitinen  9 , Santiago Abad Repiso  10 , Hesham Abdelbary  11 , Alejandro Abiad Mejia  12 , Ahmed A Abood  13 , Juan C Abril Martin  14 , Adesegun Abudu  15 , Ayman Abu Elhamd  16 , Marthelena Acosta  17 , Keisuke Ae  18 , Manish Agarwal  19 , Vivek Ajit Singh  20 , Toru Akiyama  21 , Ibrahim Alshaygy  22 , Jose I Albergo  23 , John Alexander  24 , Patricio A Alfaro  25 , Bugra Alpan  26 , Jose Amaya-Valero  27 , Megan Anderson  28 , Dimosthenis Andreou  29 , Lucas Annabell  30 , Christopher Anthony  31 , Ahmed Aoude  32 , Iraia Arteagoitia-Colino  33 , Apichat Asavamongkolkul  34 , William Aston  35 , Libe Asua Mentxaka  36 , Christine Azzopardi  15 , Thomas Baad-Hansen  37 , Ismail T Badr  38 , Francisco Baixauli-Garcia  27 , Gavin Baker  39 , Tessa Balach  40 , Giacomo G Baldi  41 , Janie Barry  42 , Georges Basile  42 , Stefano Bastoni  43 , Mohammad Basuki  44 , Henrik Bauer  45 , Lee Bayliss  31 , Ricardo G Becker  46 , Angad Bedi  47 , Joseph Benevenia  48 , Francisco Bengoa  49 , Peter Bergh  50 , Marko Bergovec  51 , Nicholas Bernthal  52 , Odion Binitie  53 , David Boddie  54 , Michele Boffano  55 , Patricia Bonilla Huertas  56 , Anna B Borgognoni  37 , Rajesh Botchu  15 , Jos Bramer  57 , Rahat Brar  58 , Harriet Branford-White  59 , Demien Broekhuis  60 , Samuel E Broida  61 , Tymoteusz Budny  62 , Zachary D Burke  63 , Jorge Cabrolier  64 , Jose A Calvo-Haro  65 , Jorge R Calvo Tapies  66 , Rodrigo Cardoso  67 , Richard Carey Smith  68 , Pedro I Carvallo  69 , Nicolas Casales Fresenga  70 , Jose M Casanova  71 , Oscar Ceballos  72 , Juan L Cebrian Parra  73 , Sara Chacon Cartaya  74 , Chung M Chan  75 , Yoon Joo Cho  76 , Peter Choong  77   78 , Yang-Guk Chung  79 , Dawid Ciechanowicz  80 , Miguel A Clara-Altamirano  81 , David Clever  82 , Sebastian M Colina  83 , Luis Consuegra  84 , Cory Couch  61 , Gillian Cribb  85 , Carlos Cuervo  86 , Laurence A Cusick  39 , Solomon Dadia  87 , Tanios Dagher  40 , Dietmar Dammerer  51 , Mark Davies  15 , Nerys Davies  15 , Luis P de la Rosa Martino  88 , Francisco J de Santos de la Fuente  89 , Marieke de Vaal  62 , Claudia Deckers  90 , Javier Delgado Obando  91 , Shaneel Deo  92 , Niklas Deventer  62 , Claudia Di Bella  93 , Gregory Domson  94 , Davide M Donati  95 , Desiree M Dorleijn  96 , Jacques Du Toit  97 , Debra Dunne  98 , Rodolfo Duran Ciarrochi  99 , Elina Ekman  100 , Ahmed M El Ghoneimy  101 , Makoto Endo  102 , Levent Eralp  103 , Mahmoud Etaiwi  15 , Scott Evans  15 , Robin Evrard  104 , Will Eward  105 , Alberto Farese  106 , Peter C Ferguson  82 , Pedro F Ferreira Cardoso  107 , Fabrice Fiorenza  108 , Michael Flint  92 , Hector Flores  109 , Joao Freitas  110 , Bruno Fuchs  111 , Tomohiro Fujiwara  112 , Philipp T Funovics  113 , Marcos Galli Serra  114 , Zakareya Gamie  115 , Carlos Garces-Zarzalejo  116 , Aaron Gazendam  82 , Carsten Gebert  117 , Jasper G Gerbers  118 , Craig Gerrand  31 , Ghaith Abou-Nouar  119 , Michelle Ghert  120 , Kanishka M Ghosh  121 , Max Gibbons  59 , Luis C Gomez-Mier  122 , Jesus Gomez-Vallejo  66 , Anne Gomez-Mascard  123 , Marcos R Gonzalez  124 , Fausto Gonzalez-Lizan  125 , Georg Gosheger  62 , Stuart Goudie  126 , Krista Goulding  127 , Stavros D Goumenos  128 , Anthony Griffin  82 , Ashish Gulia  58 , Sanjay Gupta  129 , Amit Gupta  19 , Maurice Guzman  130 , Mohammed Haitham  131 , Jendrik Hardes  132 , Francisco Hardoy  72 , Yusuf Hasan  31 , Georg Hauer  133 , Helard Havard  31 , Rex Haydon  40 , John Healey  134 , Nerea Hernandez Gonzalez  36 , Adriana Hernandez-Lopez  135 , Asle Hesla  45 , Matthew Hess  136 , Thomas Hilton  137 , Chindanai Hongsaprabhas  138 , Francis Hornicek  139 , Keith Hosking  137 , Eleanor Houghton  140 , Oluwaseyi K Idowu  141 , Joseph Ippolito  48 , Marc Isler  42 , Shintaro Iwata  142 , Jake Jagiello  143 , Neil Jenkins  15 , Thomas Jenkins  144 , Charlotte Jeys  144 , Tom Jeys  145 , Luke Johnson  143 , Andy Johnston  92 , Min Wook Joo  146 , Paul C Jutte  147 , Kadri Kaldas  148 , Amar Kamat  19 , Sudhir Kannan  31 , Bilal Kapanci  149 , Zeeshan Khan  150 , Hiroshi Kobayashi  151 , Yehuda Kollender  152 , Sebastian Koob  153 , Daniel Kotrych  80 , Richard Kyte  154 , Jose M Lamo de Espinosa  155 , Alexander L Lazarides  53 , Louis-Romee Le Nail  156 , Pawel Legosz  157 , Burkhard Lehner  158 , Andreas Leithner  133 , Maryse Lejoly  159 , Valerae O Lewis  160 , Peng Lin  161 , Francisco Linares  162 , Santiago A Lozano-Calderon  124 , Ashish Mahendra  129 , Ferdiansyah Mahyudin  163 , Fermin J Mandia Mancebo  164 , Sara M Torrejon  165 , Christian Marx  143 , Eric Mascard  166 , Jean-Camille Mattei  167 , Louise McCullough  168 , Sam McMahon  39 , Manuel R Medellin Rincon  169 , Benjamin Miller  170 , Shinji Miwa  171 , Gustavo Molina Uribe  172 , Bryan Moon  160 , Rhidian Morgan-Jones  173 , Diego J Moriel Garcesco  174 , Carol Morris  134 , Steward Morrison  175 , Sophie Mottard  42 , Marcio Moura  176 , Linde Muster  143 , Robert Nakayama  177 , Prashant Narhari  178 , Ana Navas  118 , Prakash Nayak  179 , Johannes Neugebauer  51 , Erik T Newman  124 , Jyrki Nieminen  180 , Emmy Nyqvist  45 , Lukas Nystrom  181 , Sarah O'Reilly-Harbidge  182 , Gary O'Toole  183 , Vania Oliveira  184 , André Olivier  185 , Mohamed Omar  186 , Eduardo J Ortiz-Cruz  187 , Harzem Ozger  188 , Korhan Ozkan  189 , Elisa Pala  190 , Emanuela Palmerini  95 , Grant Pang  182 , Panayiotis Papagelopoulos  191 , Giovanni Paraliticci  192 , Michael C Parry  15 , Sam Patton  193 , David Peake  15 , Ana Peiro Ibanez  194 , Israel Perez Munoz  195 , Ganapathy R Perianayagam  196 , Michael M Petersen  197 , Joris Ploegmakers  47 , Robin Pollock  31 , Gerard Powell  182 , Juan Pretell  192 , Jan Puetzler  62 , Faisal Qamar  198 , Anand Raja  199 , Raja B Rajasekaran  200 , Dipak Ramkumar  201 , R L Randall  202 , Kenneth S Rankin  203 , Kevin A Raskin  124 , Kumaran Rassppan  15 , Lauris Repsa  204 , Mickael Ropars  205 , Peter Rose  61 , Wael Sadek  16 , German Salcedo  206 , Aasim Saleemi  207 , Andrea Sambri  208 , Hartej Sar  15 , Roberto Scanferla  209 , Thomas Schubert  210 , Jan Schwarze  62 , Guido Scoccianti  211 , Ashley Scrimshire  203 , Tetsuya Sekita  142 , Ahmad Shehadeh  212 , Ahmed Shoaib  213 , Bhim Shreemal  15 , Felix Shumelinsky  149 , Geoffrey Siegel  214 , Claudio Silveri  215 , Robert Silverwood  129 , Friedl Sinnaeve  216 , Jerome Sison  15 , Andrea Slade  15 , Maria A Smolle  133 , Franz Snyman  217 , Scott Sommerville  218 , Sahil Sood  58 , Andre Spiguel  219 , Hugo St-Yves  42 , Eric L Staals  95 , Silvia Stacchiotti  220 , Nikolas Stavropoulos  221 , Peter Steadman  222 , Jonathan D Stevenson  15 , Mikaela Sullivan  61 , Gwen Sys  223 , Bartlomiej Szostakowski  224 , Angela Tamburini  225 , Yuta Taniguchi  171 , Thomas Temple  139 , Christoph Theil  62 , Joachim Thorkildsen  226 , Meagan Tibbo  227 , Roger Tillman  15 , Yu Toda  228 , Kaspar Tootsi  229 , Ferran Torner Rubies  230 , Frank Traub  231 , Ioannis Trikoupis  128 , Panagiotis Tsagkozis  45 , Kim Tsoi  82 , Hiroyuki Tsuchiya  171 , Veli-Matti Vainio  232 , Antonio Valcarcel  233 , Juan Valencia  234 , Annelies Van Beeck  235 , Michel Van de Sande  60 , Thomas Van Den Berghe  159 , Ingrid Van de Geest  90 , Lizz Van der Heijden  236 , Robert Van der Wal  118 , Kirsten Van Langevelde  60 , Gualter Vaz  237 , Roberto Velez Villa  238 , Floortje Verspoor  239 , Koenraad Verstraete  240 , Julia Visgauss  241 , Oleg Vyrva  242 , Hazem Wafa  243 , Sebastian Walter  244 , Wan F Wan Ismail  245 , Edward Wang  246 , Patrick Q Wang  42 , David Warnock  39 , Joel Werier  11 , Wolfram Weschenfelder  247 , Kwok-Chuen Wong  248 , Marjan Woulthuyzen-Bakker  249 , Jay Wunder  82 , Indica Wysinghe  15 , Norio Yamamoto  171 , Zhaoming Ye  161 , Seung-Jae Yoon  250 , Suraya Zainul Abidin  251 , Tomas Zamora  252 , Pierluca Zecchetto  253 , Liuzhe Zhang  82 , Juan P Zumarraga  83 , Domenico A Campanacci  254
Affiliations

Identifying consensus and areas for future research in chondrosarcoma : a report from the Birmingham Orthopaedic Oncology Meeting

Lee M Jeys et al. Bone Joint J. .

Abstract

Aims: The Birmingham Orthopaedic Oncology Meeting (BOOM), held in January 2024, convened 309 delegates from 53 countries to discuss and refine 21 consensus statements on the optimal management of chondrosarcoma.

Methods: With representation from Europe (43%; n = 133), North America (17%; n = 53), South America (16%; n = 49), Asia (13%; n = 40), Australasia (5%; n = 16), the Middle East (4%; n = 12), and Africa (2%; n = 6), the combined experience of treating bone sarcomas among attendees totalled approximately 30,000 cases annually, equivalent to 66 years of experience in the UK alone. The meeting's process began with the formation of a local organizing committee, regional leads, and a scientific committee comprising representatives from 150 specialist units across 47 countries. Supported by major orthopaedic oncology organizations, the meeting used a modified Delphi process to develop consensus statements through online questionnaires, thematic groupings, narrative reviews, and anonymous pre-meeting polling.

Results: Strong (> 80%) consensus was achieved on 19 out of 21 statements, reflecting agreement among delegates. Key areas of consensus included the role of radiology in diagnosis and surveillance, the management of locally recurrent disease, and the treatment of dedifferentiated chondrosarcoma. Notably, there was agreement that routine chemotherapy has no role in chondrosarcoma treatment, and radiological surveillance is safe for intraosseous chondrosarcomas. Despite the overall consensus, areas of controversy remain, particularly regarding the treatment of atypical cartilage tumours and surgical margins. These unresolved issues underscore the need for further research and collaboration within the orthopaedic oncology community.

Conclusion: BOOM represents the largest global consensus meeting in orthopaedic oncology, providing valuable guidance for clinicians managing chondrosarcoma worldwide. The consensus statements offer a reference for clinical practice, highlight key research priorities, and aim to improve patient outcomes on a global scale.

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Conflict of interest statement

L. M. Jeys reports royalties or licenses from Implantcast, payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events from Implantcast, Zimmer Biomet, and Stryker, and support for attending meetings and/or travel from Implantcast, all of which are unrelated to this study. G. V. Morris reports consulting fees, payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events, and support for attending meetings and/or travel from Implantcast, all of which are unrelated to this study. E. Botello reports consulting fees, payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events, and support for attending meetings and/or travel from Zimmer Biomet, all of which are unrelated to this study. R. A. Boyle reports payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events and support for attending meetings and/or travel from Zimmer Biomet, unrelated to this study. M. T. Houdek reports consulting fees from Link Orthopedics and Stryker, unrelated to this study. A. Puri is a member of the editorial board of The Bone & Joint Journal. P. Ruggieri reports consulting fees from Exactech and royalties or licenses from Stryker, unrelated to this study. M. Laitinen reports support for attending meetings and/or travel from Tree-Step, unrelated to this study.

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