Effects of Assisted Reproductive Technology on Genetics, Obstetrics, and Neonatal Outcomes

Abstract

The prevalence of infertility has increased in the United States over the past decade with 1 in 5 reproductive-aged women suffering from this diagnosis. The use of assisted reproductive technology (ART) to achieve pregnancy has correspondingly steadily increased. After examining the outcomes of ART births, clear trends of increased preterm birth rate, higher-order multiples, and imprinting disorders have been established among ART-related outcomes. However, the relationship between ART and birth defects, abnormal placentation, and stillbirth require further investigation. This review aims to highlight current literature surrounding ART and its relationship with key obstetrical outcomes, neonatal outcomes, and medical genetics.