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Review
. 2025 Jan 7;67(1):uiaf002.
doi: 10.1093/joccuh/uiaf002.

Adverse effects of nanoparticles on humans

Yasuo Morimoto  1 , Hiroto Izumi  1 , Taisuke Tomonaga  1 , Chinatsu Nishida  2 , Hidenori Higashi  2
Affiliations
Review

Adverse effects of nanoparticles on humans

Yasuo Morimoto et al. J Occup Health. .

Abstract

It was previously thought that the particles inhaled by humans and having adverse effects were micron-sized; particles with a particularly high content of crystalline silica were thought to have harmful effects. In recent years, manufactured materials have been further refined to nano-level particles, and it has been reported that these ultrafine particles have different adverse effects, making it necessary to perform occupational health management for chemicals that differ from micron-sized particles. Here we report the adverse effects of carbon nanotubes, welding fumes, and organic substances as examples of nanoparticles.

Keywords: carbon nanotube; lung; nanoparticle; polyacrylic acid; welding fume; worker.

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Conflict of interest statement

None declared.

References

    1. Takagi A, Hirose A, Nishimura T, et al. Induction of mesothelioma in p53+/− mouse by intraperitoneal application of multi-wall carbon nanotube. J Toxicol Sci. 2008;33(1):105-116. 10.2131/jts.33.105 - DOI - PubMed
    1. Morimoto Y, Kobayashi N, Shinohara N, Myojo T, Tanaka I, Nakanishi J. Hazard assessments of manufactured nanomaterials. J Occup Health. 2010;52(6):325-334. 10.1539/joh.R10003 - DOI - PubMed
    1. Kasai T, Umeda Y, Ohnishi M, et al. Lung carcinogenicity of inhaled multi-walled carbon nanotube in rats. Part Fibre Toxicol. 2016;13(1):53. 10.1186/s12989-016-0164-2 - DOI - PMC - PubMed
    1. Pauluhn J. Subchronic 13-week inhalation exposure of rats to multiwalled carbon nanotubes: toxic effects are determined by density of agglomerate structures, not fibrillar structures. Toxicol Sci. 2010;113(1):226-242. 10.1093/toxsci/kfp247 - DOI - PubMed
    1. Ma-Hock L, Treumann S, Strauss V, et al. Inhalation toxicity of multiwall carbon nanotubes in rats exposed for 3 months. Toxicol Aci. 2009;112(2):468-481. 10.1093/toxsci/kfp146 - DOI - PubMed

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