Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2025 Feb 1;317(1):324.
doi: 10.1007/s00403-024-03697-4.

Silicone gel versus combination of silicone gel and a 577-nm diode laser in the treatment of post-surgery hypertrophic scar (comparative study)

Essam-Elden M Mohamed  1 , Hazem L Abd-Elaleem  1 , Samar Ali Abodief Zahran  2
Affiliations
Randomized Controlled Trial

Silicone gel versus combination of silicone gel and a 577-nm diode laser in the treatment of post-surgery hypertrophic scar (comparative study)

Essam-Elden M Mohamed et al. Arch Dermatol Res. .

Abstract

Background: Hypertrophic scars, resulting from alterations in the normal processes of cutaneous wound healing, are characterized by proliferation of dermal tissue with excessive deposition of fibroblast-derived extracellular matrix proteins, especially collagen, over long periods, and by persistent inflammation and fibrosis. The present study aim to compare the efficacy of silicone gel versus combination of a 577-nm pro- yellow laser and silicone gel in the treatment of post-surgery hypertrophic scar.

Methods: This study is a randomized comparative study In the period from 14 January 2021 up to the end of January 2023. 30 patients with post-surgery hypertrophic scar divided into two groups: A: one half of scar was managed with 577 nm diode laser 3 sessions monthly combined with application of silicone gel at home. A + B: the entire scar was treated with silicone gel within six months who admitted to the Laser unit of the Dermatology and Andrology Department at Al-Azhar University Hospital, Assiut during the study period.

Results: Significant improvement in pigmentation, pliability, height and total Vancouver score. By comparing between silicone gel and combination of silicone gel and a 577 nm diode laser, the combination shows significant improving than silicone gel alone. The scar in the lip and breast area showed a significant higher improvement rate with yellow laser plus silicone gel compared to the other site.

Conclusion: Combination of silicone gel and yellow laser has significant effect in making surgical scars less distinct.

Keywords: 577 nm; Diode laser; Scar; Silicon gel; Surgical scar; Yellow laser.

PubMed Disclaimer

Conflict of interest statement

Declarations. Competing interests: The authors declare no competing interests.

References

    1. Namazi MR, Fallahzadeh MK, Schwartz RA (2011) Strategies for prevention of scars: what can we learn from fetal skin? Int J Dermatol 50(1):85–93 - DOI - PubMed
    1. Bakker A, Maertens KJ, Van Son MJ, Van Loey NE (2013) Psychological consequences of pediatric burns from a child and family perspective: a review of the empirical literature. Clin Psychol Rev 33(3):361–371 - DOI - PubMed
    1. Coentro JQ, Pugliese E, Hanley G, Raghunath M, Zeugolis DI (2019) Current and upcoming therapies to modulate skin scarring and fibrosis. Adv Drug Deliv Rev 146:37–59 - DOI - PubMed
    1. De Decker I, Hoeksema H, Verbelen J, Vanlerberghe E, De Coninck P, Speeckaert MM, Blondeel P, Monstrey S, Claes KE (2022) The use of fluid silicone gels in the prevention and treatment of hypertrophic scars: a systematic review and meta- analysis. Burns 48(3):491–509 - DOI - PubMed
    1. De Las Alas JMG, Siripunvarapon AH, Dofitas BL (2012) Pulsed dye laser for the treatment of keloid and hypertrophic scars: a systematic review. Expert Rev Med Dev 9(6):641–650 - DOI

Publication types

LinkOut - more resources