Epidemiology and temporal trends of adult inflammatory bowel disease in Taiwan: Multicenter study from the TSIBD registration

Chih-Wen Huang¹, Shu-Chen Wei², Ming-Jium Shieh³, Jen-Wei Chou⁴, Chiao-Hsiung Chuang⁵, Horng-Yuan Wang⁶, Chen-Wang Chang⁶, Deng-Chyang Wu⁷, Tien-Yu Huang⁸, Yu-Hwa Liu⁹, Tzung-Jiun Tsai¹⁰, Wei-Chen Tai¹¹, Chi-Ming Tai¹², Chen-Shuan Chung¹³, Wen-Sy Tsai¹⁴, Chung-Hsin Chang¹⁵, Ching-Pin Lin¹⁶, Hsi-Chang Lee¹⁷, Chun-Chao Chang¹⁸, I-Che Feng¹⁹, Chun-Chi Lin²⁰, Mu-Liang Cheng²¹, Hsu-Heng Yen²²

Affiliations

¹ Division of Gastroenterology, Changhua Christian Hospital, Changhua, Taiwan; Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan; Taiwan Society of Inflammatory Bowel Disease (TSIBD), Taiwan.
² Taiwan Society of Inflammatory Bowel Disease (TSIBD), Taiwan; Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
³ Taiwan Society of Inflammatory Bowel Disease (TSIBD), Taiwan; Department of Oncology, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan.
⁴ Taiwan Society of Inflammatory Bowel Disease (TSIBD), Taiwan; Center for Digestive Medicine, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan; School of Chinese Medicine, China Medical University, Taichung, Taiwan.
⁵ Taiwan Society of Inflammatory Bowel Disease (TSIBD), Taiwan; Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
⁶ Taiwan Society of Inflammatory Bowel Disease (TSIBD), Taiwan; Division of Gastroenterology, Department of Internal Medicine, MacKay Memorial Hospital, Taipei, Taiwan; MacKay Junior College of Medicine, Nursing and Management, Taipei, Taiwan.
⁷ Taiwan Society of Inflammatory Bowel Disease (TSIBD), Taiwan; Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Gangshan Hospital, Kaohsiung, Taiwan; Department of Medicine, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Regenerative Medicine and Cell Therapy Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan.
⁸ Taiwan Society of Inflammatory Bowel Disease (TSIBD), Taiwan; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
⁹ Taiwan Society of Inflammatory Bowel Disease (TSIBD), Taiwan; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan.
¹⁰ Taiwan Society of Inflammatory Bowel Disease (TSIBD), Taiwan; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; School of Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
¹¹ Taiwan Society of Inflammatory Bowel Disease (TSIBD), Taiwan; Division of Hepatogastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.
¹² Taiwan Society of Inflammatory Bowel Disease (TSIBD), Taiwan; Division of Gastroenterology and Hepatology, Department of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan; School of Medicine for International Students, College of Medicine, I-Shou University, Kaohsiung, Taiwan.
¹³ Taiwan Society of Inflammatory Bowel Disease (TSIBD), Taiwan; Division of Gastroenterology and Hepatology, Far Eastern Memorial Hospital, New Taipei, Taiwan; Ultrasonography and Endoscopy Center, Far Eastern Memorial Hospital, New Taipei City, Taiwan.
¹⁴ Taiwan Society of Inflammatory Bowel Disease (TSIBD), Taiwan; Division of Colon and Rectal Surgery, Colorectal Section, Department of Surgery Chang, Gung Memorial Hospital, Taoyuan City, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan.
¹⁵ Taiwan Society of Inflammatory Bowel Disease (TSIBD), Taiwan; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
¹⁶ Taiwan Society of Inflammatory Bowel Disease (TSIBD), Taiwan; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan; Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan; School of Medicine, Chung Shan Medical University, Taichung, Taiwan.
¹⁷ Taiwan Society of Inflammatory Bowel Disease (TSIBD), Taiwan; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Renai Branch, Taipei City Hospital, Taipei, Taiwan.
¹⁸ Taiwan Society of Inflammatory Bowel Disease (TSIBD), Taiwan; TMU Research Center for Digestive Medicine, Taipei Medical University, Taipei, 110301, Taiwan; Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan.
¹⁹ Taiwan Society of Inflammatory Bowel Disease (TSIBD), Taiwan; Division of Gastroenterology and Hepatology, Chi Mei Medical Center, Tainan, Taiwan.
²⁰ Taiwan Society of Inflammatory Bowel Disease (TSIBD), Taiwan; Division of Colon & Rectal Surgery, Department of Surgery Taipei Veterans General Hospital Taipei Taiwan, Taiwan; Department of Surgery, Faculty of Medicine, School of Medicine National Yang Ming Chiao Tung University Taipei Taiwan, Taiwan.
²¹ Taiwan Society of Inflammatory Bowel Disease (TSIBD), Taiwan; Department of Gastroenterology, Mennonite Christian Hospital, Hualien, Taiwan.
²² Division of Gastroenterology, Changhua Christian Hospital, Changhua, Taiwan; Taiwan Society of Inflammatory Bowel Disease (TSIBD), Taiwan; Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan. Electronic address: 91646@cch.org.tw.

PMID: 39893095
DOI: 10.1016/j.jfma.2025.01.018

Free article

Epidemiology and temporal trends of adult inflammatory bowel disease in Taiwan: Multicenter study from the TSIBD registration

Chih-Wen Huang et al. J Formos Med Assoc. 2025.

Free article

. 2025 Jan 31:S0929-6646(25)00034-8.

doi: 10.1016/j.jfma.2025.01.018. Online ahead of print.

Authors

Affiliations

¹ Division of Gastroenterology, Changhua Christian Hospital, Changhua, Taiwan; Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan; Taiwan Society of Inflammatory Bowel Disease (TSIBD), Taiwan.
² Taiwan Society of Inflammatory Bowel Disease (TSIBD), Taiwan; Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
³ Taiwan Society of Inflammatory Bowel Disease (TSIBD), Taiwan; Department of Oncology, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan.
⁴ Taiwan Society of Inflammatory Bowel Disease (TSIBD), Taiwan; Center for Digestive Medicine, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan; School of Chinese Medicine, China Medical University, Taichung, Taiwan.
⁵ Taiwan Society of Inflammatory Bowel Disease (TSIBD), Taiwan; Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
⁶ Taiwan Society of Inflammatory Bowel Disease (TSIBD), Taiwan; Division of Gastroenterology, Department of Internal Medicine, MacKay Memorial Hospital, Taipei, Taiwan; MacKay Junior College of Medicine, Nursing and Management, Taipei, Taiwan.
⁷ Taiwan Society of Inflammatory Bowel Disease (TSIBD), Taiwan; Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Gangshan Hospital, Kaohsiung, Taiwan; Department of Medicine, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Regenerative Medicine and Cell Therapy Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan.
⁸ Taiwan Society of Inflammatory Bowel Disease (TSIBD), Taiwan; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
⁹ Taiwan Society of Inflammatory Bowel Disease (TSIBD), Taiwan; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan.
¹⁰ Taiwan Society of Inflammatory Bowel Disease (TSIBD), Taiwan; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; School of Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
¹¹ Taiwan Society of Inflammatory Bowel Disease (TSIBD), Taiwan; Division of Hepatogastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.
¹² Taiwan Society of Inflammatory Bowel Disease (TSIBD), Taiwan; Division of Gastroenterology and Hepatology, Department of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan; School of Medicine for International Students, College of Medicine, I-Shou University, Kaohsiung, Taiwan.
¹³ Taiwan Society of Inflammatory Bowel Disease (TSIBD), Taiwan; Division of Gastroenterology and Hepatology, Far Eastern Memorial Hospital, New Taipei, Taiwan; Ultrasonography and Endoscopy Center, Far Eastern Memorial Hospital, New Taipei City, Taiwan.
¹⁴ Taiwan Society of Inflammatory Bowel Disease (TSIBD), Taiwan; Division of Colon and Rectal Surgery, Colorectal Section, Department of Surgery Chang, Gung Memorial Hospital, Taoyuan City, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan.
¹⁵ Taiwan Society of Inflammatory Bowel Disease (TSIBD), Taiwan; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
¹⁶ Taiwan Society of Inflammatory Bowel Disease (TSIBD), Taiwan; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan; Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan; School of Medicine, Chung Shan Medical University, Taichung, Taiwan.
¹⁷ Taiwan Society of Inflammatory Bowel Disease (TSIBD), Taiwan; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Renai Branch, Taipei City Hospital, Taipei, Taiwan.
¹⁸ Taiwan Society of Inflammatory Bowel Disease (TSIBD), Taiwan; TMU Research Center for Digestive Medicine, Taipei Medical University, Taipei, 110301, Taiwan; Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan.
¹⁹ Taiwan Society of Inflammatory Bowel Disease (TSIBD), Taiwan; Division of Gastroenterology and Hepatology, Chi Mei Medical Center, Tainan, Taiwan.
²⁰ Taiwan Society of Inflammatory Bowel Disease (TSIBD), Taiwan; Division of Colon & Rectal Surgery, Department of Surgery Taipei Veterans General Hospital Taipei Taiwan, Taiwan; Department of Surgery, Faculty of Medicine, School of Medicine National Yang Ming Chiao Tung University Taipei Taiwan, Taiwan.
²¹ Taiwan Society of Inflammatory Bowel Disease (TSIBD), Taiwan; Department of Gastroenterology, Mennonite Christian Hospital, Hualien, Taiwan.
²² Division of Gastroenterology, Changhua Christian Hospital, Changhua, Taiwan; Taiwan Society of Inflammatory Bowel Disease (TSIBD), Taiwan; Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan. Electronic address: 91646@cch.org.tw.

PMID: 39893095
DOI: 10.1016/j.jfma.2025.01.018

Abstract

Background: Despite industrialization and advances in healthcare, the prevalence of inflammatory bowel disease (IBD), which encompasses Crohn's disease (CD) and ulcerative colitis (UC), is increasing in Taiwan. Population-based studies can estimate the incidence or prevalence of IBD; however, there is a lack of information regarding the disease phenotype. Therefore, this study was designed to investigate the epidemiologic trends of IBD in Taiwan to gain a more comprehensive understanding.

Methods: Patient data were reviewed from a prospectively registered study by the Taiwan Society of IBD (TSIBD).

Results: We collected data from 2752 patients with IBD, of whom 881 had CD and 1871 had UC. Their average age was 41.99 ± 15.19 years. The CD group had more male patients than the UC group (67.88% vs. 60.72%; p < .001). The rates of appendectomy, bowel resection, and surgery for perianal disease before IBD diagnosis, along with the increased use of steroids, immunomodulators, and biologics, were higher in the CD group. From 2005 to 2023, the ratio of UC to CD cases in Taiwan decreased, the proportions of patients with colonic and penetrating CD also declined, and the proportion of patients with UC exhibiting ulcerative proctitis increased.

Conclusion: In Taiwan, similar to high-income countries, the ratio of UC to CD cases has declined. The reduced of colonic and penetrating CD indicates that diagnostic awareness has improved and colonoscopic examination has become more comprehensive in Taiwan.

Keywords: Crohn's disease; Epidemiology; Inflammatory bowel disease; Taiwan; Ulcerative colitis.

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Declarations of competing interest None.

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Epidemiology and temporal trends of adult inflammatory bowel disease in Taiwan: Multicenter study from the TSIBD registration

Affiliations

Epidemiology and temporal trends of adult inflammatory bowel disease in Taiwan: Multicenter study from the TSIBD registration

Authors

Affiliations

Abstract

Conflict of interest statement

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Full Text Sources