ASO Author Reflections: Complete Pathological Response after Neoadjuvant Treatment for Pancreatic Ductal Adenocarcinomas-Curative Surgery in Cured Patients?

Pietro Addeo¹, Milena Muzzolini², Christophe Laurent³, Bruno Heyd⁴, Alain Sauvanet², Jonathan Garnier⁵, Marie Sophie Alfano⁵, Sebastien Gaujoux⁶, Charles De Ponthaud⁶, Ugo Marchese⁷, Doris Da Silva⁷, Emmanuel Buc⁸, Regis Souche⁹, Jean Michel Fabre⁹, Pierre-Emanuel Colombo¹⁰, Lorenzo Ferre¹⁰, Maxime Foguenne¹¹, Catherine Hubert¹¹, Mehdi El Amrani¹², Stephanie Truant¹², Lilian Schwartz¹³, Nicolas Regenet¹⁴, Aurelien Dupre¹⁵, Raffaele Brustia¹⁶, Rim Cherif¹⁶, Julie Navez¹⁷, Benjamin Darnis¹⁸, Olivier Facy¹⁹, Robin Grellet¹⁹, Guillaume Piessen²⁰, Julie Veziant²⁰, Rami Rhaiem²¹, Reza Kianmanesh²¹, Elena Fernandez-De-Sevilla²², Maximiliano Gelli²², Abdelkader Taibi²³, Pauline Georges²⁴, Jean Yves Mabrut²⁴, Mickael Lesurtel², Alexandre Doussot⁴, Philippe Bachellier²⁵

Affiliations

¹ Hepato-Pancreato-Biliary Surgery and Liver Transplantation, Pôle des Pathologies Digestives et Hépatiques, Hôpital de Hautepierre-Hôpitaux Universitaires de Strasbourg, Université de Strasbourg, Strasbourg, France. pietrofrancesco.addeo@chru-strasbourg.fr.
² Department of HBP Surgery, AP-HP, Hôpital Beaujon, University of Paris, Clichy, France.
³ Department of Digestive Surgery, Centre Magellan, CHU Bordeaux, Bordeaux, France.
⁴ Department of Digestive Surgical Oncology, University Hospital of Besançon, Besançon, France.
⁵ Department of Oncological Surgery, Institut Paoli Calmettes, Marseille University, Marseille, France.
⁶ Department of Hepato-Biliary and Pancreatic Surgery and Liver Transplantation, AP-HP, Pitié-Salpêtrière Hospital, Paris, France.
⁷ Department of Digestive, Hepatobiliary and Pancreatic Surgery, Cochin Hospital, AP-HP, Université de Paris, Paris, France.
⁸ Department of Digestive and Hepatobiliary Surgery, Liver Transplantation, University Hospital Clermont-Ferrand, Clermont-Ferrand, France.
⁹ Department of Surgery, Hopital Saint Eloi, Montpellier, France.
¹⁰ Department of Surgical Oncology, Institut du Cancer de Montpellier, Montpellier, France.
¹¹ Department of Abdominal Surgery and Transplantation, Cliniques universitaires Saint-Luc, Brussels, Belgium.
¹² Department of Digestive Surgery and Transplantation, Lille University Hospital, Lille, France.
¹³ Department of Digestive Surgery, Rouen University Hospital and Université de Rouen Normandie, Rouen, France.
¹⁴ Department of Digestive Surgery, Nantes Hospital, Nantes, France.
¹⁵ Department of Surgical Oncology, Centre Léon Bérard, Lyon, France.
¹⁶ Department of Digestive and Hepato-Pancreatic-Biliary Surgery, Hôpital Henri-Mondor, AP-HP, Paris Est Créteil University, UPEC, Créteil, France.
¹⁷ Department of Abdominal Surgery and Transplantation, Hôpitaux Universitaires de Bruxelles, Hopital Erasme, Université Libre de Bruxelles, Brussels, Belgium.
¹⁸ Department of Digestive Surgery, Clinique de La Sauvegarde, Lyon, France.
¹⁹ Department of Digestive and Surgical Oncology, University Hospital, Dijon, France.
²⁰ Department of Digestive and Oncological Surgery, Claude Huriez University Hospital, Lille, France.
²¹ Department of HBP and Digestive Oncological Surgery, Robert Debré University Hospital, University Reims Champagne-Ardenne, Reims, France.
²² Gustave Roussy Campus Center, Villejuif, France.
²³ Department of Digestive Surgery, Dupuytren Limoges University Hospital, Limoges, France.
²⁴ Department of General Surgery and Liver Transplantation, Croix-Rousse University Hospital, Hospices Civils de Lyon, University of Lyon I, Lyon, France.
²⁵ Hepato-Pancreato-Biliary Surgery and Liver Transplantation, Pôle des Pathologies Digestives et Hépatiques, Hôpital de Hautepierre-Hôpitaux Universitaires de Strasbourg, Université de Strasbourg, Strasbourg, France.

PMID: 39893336
DOI: 10.1245/s10434-025-16925-6

ASO Author Reflections: Complete Pathological Response after Neoadjuvant Treatment for Pancreatic Ductal Adenocarcinomas-Curative Surgery in Cured Patients?

Pietro Addeo et al. Ann Surg Oncol. 2025 Apr.

. 2025 Apr;32(4):2861-2863.

doi: 10.1245/s10434-025-16925-6. Epub 2025 Feb 1.

Authors

Affiliations

¹ Hepato-Pancreato-Biliary Surgery and Liver Transplantation, Pôle des Pathologies Digestives et Hépatiques, Hôpital de Hautepierre-Hôpitaux Universitaires de Strasbourg, Université de Strasbourg, Strasbourg, France. pietrofrancesco.addeo@chru-strasbourg.fr.
² Department of HBP Surgery, AP-HP, Hôpital Beaujon, University of Paris, Clichy, France.
³ Department of Digestive Surgery, Centre Magellan, CHU Bordeaux, Bordeaux, France.
⁴ Department of Digestive Surgical Oncology, University Hospital of Besançon, Besançon, France.
⁵ Department of Oncological Surgery, Institut Paoli Calmettes, Marseille University, Marseille, France.
⁶ Department of Hepato-Biliary and Pancreatic Surgery and Liver Transplantation, AP-HP, Pitié-Salpêtrière Hospital, Paris, France.
⁷ Department of Digestive, Hepatobiliary and Pancreatic Surgery, Cochin Hospital, AP-HP, Université de Paris, Paris, France.
⁸ Department of Digestive and Hepatobiliary Surgery, Liver Transplantation, University Hospital Clermont-Ferrand, Clermont-Ferrand, France.
⁹ Department of Surgery, Hopital Saint Eloi, Montpellier, France.
¹⁰ Department of Surgical Oncology, Institut du Cancer de Montpellier, Montpellier, France.
¹¹ Department of Abdominal Surgery and Transplantation, Cliniques universitaires Saint-Luc, Brussels, Belgium.
¹² Department of Digestive Surgery and Transplantation, Lille University Hospital, Lille, France.
¹³ Department of Digestive Surgery, Rouen University Hospital and Université de Rouen Normandie, Rouen, France.
¹⁴ Department of Digestive Surgery, Nantes Hospital, Nantes, France.
¹⁵ Department of Surgical Oncology, Centre Léon Bérard, Lyon, France.
¹⁶ Department of Digestive and Hepato-Pancreatic-Biliary Surgery, Hôpital Henri-Mondor, AP-HP, Paris Est Créteil University, UPEC, Créteil, France.
¹⁷ Department of Abdominal Surgery and Transplantation, Hôpitaux Universitaires de Bruxelles, Hopital Erasme, Université Libre de Bruxelles, Brussels, Belgium.
¹⁸ Department of Digestive Surgery, Clinique de La Sauvegarde, Lyon, France.
¹⁹ Department of Digestive and Surgical Oncology, University Hospital, Dijon, France.
²⁰ Department of Digestive and Oncological Surgery, Claude Huriez University Hospital, Lille, France.
²¹ Department of HBP and Digestive Oncological Surgery, Robert Debré University Hospital, University Reims Champagne-Ardenne, Reims, France.
²² Gustave Roussy Campus Center, Villejuif, France.
²³ Department of Digestive Surgery, Dupuytren Limoges University Hospital, Limoges, France.
²⁴ Department of General Surgery and Liver Transplantation, Croix-Rousse University Hospital, Hospices Civils de Lyon, University of Lyon I, Lyon, France.
²⁵ Hepato-Pancreato-Biliary Surgery and Liver Transplantation, Pôle des Pathologies Digestives et Hépatiques, Hôpital de Hautepierre-Hôpitaux Universitaires de Strasbourg, Université de Strasbourg, Strasbourg, France.

PMID: 39893336
DOI: 10.1245/s10434-025-16925-6

No abstract available

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Conflict of interest statement

Disclosure: The authors have no conflicts of interest to declare.

References

1. Stoop TF, Theijse RT, Seelen LWF, et al. Preoperative chemotherapy, radiotherapy and surgical decision-making in patients with borderline resectable and locally advanced pancreatic cancer. Nat Rev Gastroenterol Hepatol. 2024;21:101–24. - DOI - PubMed
1. Springfeld C, Ferrone CR, Katz MHG, et al. Neoadjuvant therapy for pancreatic cancer. Nat Rev Clin Oncol. 2023;20:318–37. - DOI - PubMed
1. Janssen QP, Buettner S, Suker M, et al. Neoadjuvant FOLFIRINOX in patients with borderline resectable pancreatic cancer: a systematic review and patient-level meta-analysis. J Natl Cancer Inst. 2019;111:782–94. - DOI - PubMed - PMC
1. Cecchini M, Salem RR, Robert M, et al. Perioperative modified FOLFIRINOX for resectable pancreatic cancer: a nonrandomized controlled trial. JAMA Oncol. 2024;10:1027. - DOI - PubMed - PMC
1. Goetze TO, Reichart A, Bankstahl US, et al. Adjuvant gemcitabine versus neoadjuvant/adjuvant FOLFIRINOX in resectable pancreatic cancer: the randomized multicenter phase II NEPAFOX trial. Ann Surg Oncol. 2024;31:4073–83. - DOI - PubMed - PMC

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ASO Author Reflections: Complete Pathological Response after Neoadjuvant Treatment for Pancreatic Ductal Adenocarcinomas-Curative Surgery in Cured Patients?

Affiliations

ASO Author Reflections: Complete Pathological Response after Neoadjuvant Treatment for Pancreatic Ductal Adenocarcinomas-Curative Surgery in Cured Patients?

Authors

Affiliations

Conflict of interest statement

References

LinkOut - more resources

Full Text Sources