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Review
. 2025 Feb 2;42(3):61.
doi: 10.1007/s12032-025-02608-5.

Molecular mechanism of genetic, epigenetic, and metabolic alteration in lung cancer

Sheeri Fatima  1 , Vineet Kumar  2 , Dhruv Kumar  3
Affiliations
Review

Molecular mechanism of genetic, epigenetic, and metabolic alteration in lung cancer

Sheeri Fatima et al. Med Oncol. .

Abstract

Lung cancer, a leading cause of cancer-related deaths worldwide, is primarily linked to smoking, tobacco use, air pollution, and exposure to hazardous chemicals. Genetic alterations, particularly in oncogenes like RAS, EGFR, MYC, BRAF, HER, and P13K, can lead to metabolic changes in cancer cells. These cells often rely on glycolysis for energy production, even in the presence of oxygen, a phenomenon known as aerobic glycolysis. This metabolic shift, along with other alterations, contributes to cancer cell growth and survival. To develop effective therapies, it's crucial to understand the genetic and metabolic changes that drive lung cancer. This review aims to identify specific genes associated with these metabolic alterations and screen phytochemicals for their potential to target these genes. By targeting both genetic and metabolic pathways, we hope to develop innovative therapeutic approaches to combat lung cancer.

Keywords: Genetic mutations; Lung cancer; Metabolic alterations; Phytochemicals; Therapeutic approaches.

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Conflict of interest statement

Declarations. Conflict of interest: The authors declare no conflict of interest. Ethical approval: Not applicable.

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