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Comment
. 2025 Feb 3;135(3):e188784.
doi: 10.1172/JCI188784.

Blood pressure regulation through circadian variation: PRDM16 as a target in vascular smooth muscle cells

M Adriana Cuibus, Omar Abdel-Wahab
Comment

Blood pressure regulation through circadian variation: PRDM16 as a target in vascular smooth muscle cells

M Adriana Cuibus et al. J Clin Invest. .

Abstract

The precise mechanisms of blood pressure (BP) regulation are not fully elucidated, and understanding BP regulation is crucial for managing hypertension and improving outcomes for cardiovascular disease. In this issue of the JCI, Wang et al. identified the transcription factor PR domain-containing protein 16 (PRDM16) as a regulator of both vascular smooth muscle cell contraction and the circadian response to BP control. PRDM16 directly transcriptionally controlled the expression of the adrenergic receptor α 1d and several clock genes crucial for BP circadian regulation. These findings identify a mechanism of how molecular pathways govern circadian BP variation, highlighting PRDM16 as a potential target for hypertension.

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Conflict of interest statement

Conflict of interest: OAW is a founder and scientific advisor of Codify Therapeutics, holds equity in this company, and receives research funding from this company. OAW has served as a consultant for Foundation Medicine Inc., Merck, Prelude Therapeutics, Amphista Therapeutics, MagnetBio, and Janssen, and is on the scientific advisory board of Envisagenics Inc., Harmonic Discovery Inc., and Pfizer Boulder. OAW has received prior research funding from H3B Biomedicine, Nurix Therapeutics, Minovia Therapeutics, and LOXO Oncology.

Figures

Figure 1
Figure 1. PRDM16 is a transcriptional regulator of BP circadian variation.
(A) PRDM16 directly transcriptionally regulates expression of the ADRA1D and core clock genes Bmal1, Cry2, and Npas2. (B) Loss of PRDM16 in VASMCs leads to a nondipping, dysregulated circadian response in systolic BP (SBP) and diastolic BP (DBP). ZT, Zeitgeber time.
See this image and copyright information in PMC

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  • Vascular smooth muscle cell PRDM16 regulates circadian variation in blood pressure

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