Non-coding RNA in the Regulation of Gastric Cancer Tumorigenesis: Focus on microRNAs and Exosomal microRNAs

Abstract

Gastric cancer has become the leading type of cancer on an international scale, with metastatic cancer being the leading cause of mortality associated with this illness. Consequently, methods for early detection have been established, mainly through the use of non-invasive biomarkers present in different bodily fluids. Exosomes are distinct extracellular vehicles that transport cellular signals over long distances via diverse contents. They may be readily seen in bodily fluids due to their secretion by gastric cancer cells or cells in the gastric cancer-tumor microenvironment. Given this context, multiple biological and functional features of human tumors, especially gastric cancer, are intricately connected to exosomal non-coding RNAs (ncRNAs). Exosomal microRNAs play a crucial role in several stages of gastric cancer progression, facilitating the transfer of genetic information between cancer cells and other cells. This process regulates tumor angiogenesis, growth, metastasis, immunological responses, and medication resistance. They engage with several regulatory complexes that have different enzymatic activities. These complexes then alter the chromatin landscapes, including changes to nucleosomes, DNA methylation, and alterations to histones. This research delves into the essential regulatory mechanisms of exosomes in gastric cancer. Furthermore, the existing understanding of the functions of exosomal miRNAs in this context was evaluated, aiming to confirm their potential significance in identifying biomarkers, elucidating their roles in immune evasion and drug resistance, and ultimately evaluating therapeutic strategies.

Keywords: Non-coding RNA; exosomal microRNAs; gastric cancer; ncRNA; tumorigenesis.

Fig. 1

MiRNAs modulate the chemoresistance of chemoresistanceer cells. PTEN; Phosphatase and tensin homolog: TGFBR; Transforming growth factor beta receptor 1: ANK; Ankyrin 1: ANXA; Annexin A1: CAPNS; Calpain Small Subunit 1: MDR; Multidrug- resistance: RECK; Reversion inducing cysteine rich protein with kazal motifs; HMGA; High mobility group A; 5-FU; 5-Fluorouracil: VCR; Vestibulocollic reflex: CDDP; cis- diamminedichloroplatinum: SIRT; Selective internal radiation therapy.