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. 2025 Jan 17:12:1487121.
doi: 10.3389/fped.2024.1487121. eCollection 2024.

Genetic screening strategy for children with hereditary spherocytosis in Jiangxi Province of China

Chongjun Wu  1   2 , Zhongjin Xu  1   2 , Qian Wan  1   2 , Feng Chen  1   2 , Yao Ye  1   2 , Hong Wang  1   2
Affiliations

Genetic screening strategy for children with hereditary spherocytosis in Jiangxi Province of China

Chongjun Wu et al. Front Pediatr. .

Abstract

Objective: This study aims to provide a comprehensive summary of the clinical phenotypic characteristics of children with anemia of unknown etiology, particularly focusing on the early detection of hereditary spherocytosis (HS) and exploring genetic screening strategies for this condition in childhood.

Methods: The study included children with anemia whose underlying cause could not be definitively identified through routine clinical diagnosis. Clinical data was collected and genetic diagnosis of HS was confirmed using next-generation sequencing. Statistical analysis was conducted to evaluate the clinical characteristics of children with HS.

Results: A total of thirty children with unexplained anemia were included in the study, resulting in a gene detection diagnostic rate of 80%. This included the identification of five non-HS-related congenital anemia genes (16.66%, 5/30) and nineteen cases of hereditary spherocytosis (HS). Upon initial diagnosis, the clinical features of HS were not significantly distinct compared to other forms of anemia.

Conclusion: In Jiangxi, China, our strategy of genetic screening for these children is feasible after excluding the common causes of anemia, such as nutritional anemia, G-6-PD deficiency, thalassemia, autoimmune hemolytic anemia, and myelopoietic abnormalities in children. This is an exploration to establish a genetic screening strategy for children with HS, and more detailed genetic screening strategies need to be further studied and explored. Next-generation sequencing remains the main method for the diagnosis and differential diagnosis of HS.

Keywords: China; Jiangxi province; children; genetic screening strategy; hereditary spherocytosis.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Comparison of clinical characteristics of HS and other congenital Anemia.
Figure 2
Figure 2
Comparison of clinical characteristics between HS and gene-negative Anemia of unknown origin.
Figure 3
Figure 3
Comparison of clinical characteristics between HS and AIHA.
Figure 4
Figure 4
Comparison of clinical characteristics between HS and thalassemia.
See this image and copyright information in PMC

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