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Review
. 2025 Jan 17:15:1520008.
doi: 10.3389/fphys.2024.1520008. eCollection 2024.

Brugada syndrome update

Tingting Xu  1 , Shaokun Wang  1 , Jiawen Wang  2 , Jihong Xing  1
Affiliations
Review

Brugada syndrome update

Tingting Xu et al. Front Physiol. .

Abstract

Brugada syndrome (BrS), a genetic disorder affecting cardiac ion channels, predominantly manifests due to mutations that impair the function of the Nav1.5 sodium channel's α-subunit. This condition, identified by Josep and Pedro Brugada, is often marked by symptoms such as syncope and episodes of polymorphic ventricular tachycardia (PVT) or ventricular fibrillation (VF). These arrhythmias, if not managed promptly, can escalate to sudden cardiac death (SCD), notably in patients whose cardiac structure appears normal. Given this, the prompt recognition and stratification of individuals at elevated risk are critical. This review elaborates on the current insights into BrS, focusing on recent diagnostic techniques, risk assessment strategies, and therapeutic advancements. It also critically examines ongoing controversies in the field.

Keywords: Brugada syndrome; implantable cardioverter defibrillator; quinidine; radiofrequency ablation; right ventricular outflow tract.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Diagnosis of BrS based on Latest Expert Consensus Report (Antzelevitch et al., 2016b). (A) Display standard flow chart; (B) Shanghai Score System including other risk factors requiring BrS diagnosis (Marsman et al., 2022). (Reproduced with permission from: E Madelief J Marsman et al. BrS: update and future perspectives. Heart 2022; 108:668–675).
See this image and copyright information in PMC

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