Sources of input to interneurones mediating group I non-reciprocal inhibition of motoneurones in the cat

Abstract

Intracellular recordings have been made from laminae V-VI interneurones interposed in pathways of non-reciprocal inhibition of motoneurones from group I afferents of triceps surae and/or plantaris. A comparison of actions of brief stretches of triceps surae and plantaris with actions of electrical stimulation of nerves of these muscles revealed that I a afferents influenced about a half of the interneurones excited by I b afferents. Electrical stimulation of seven muscles nerves, three cutaneous nerves, posterior knee joint and interosseous nerves, the red nucleus and the pyramidal tract, evoked excitatory post-synaptic potentials (e.p.s.p.s) in various proportions of interneurones. Most of the interneurones were excited monosynaptically, or both monosynaptically and disynaptically by group I afferents. This, together with a very small proportion of interneurones in which e.p.s.p.s were evoked only disynaptically, indicates that the same last-order interneurones may subserve di- and trisynaptically evoked inhibition of motoneurones. Other fibre systems excited these interneurones monosynaptically (interosseal, rubro- and corticospinal), disynaptically (cutaneous, rubro- and corticospinal) and polysynaptically. The coupling of the earliest e.p.s.p.s from group II and joint afferents could not be established, but was consistent with their mediation by only one or two interposed interneurones. Inhibition was evoked from all fibre systems with excitatory input to the same or to other interneurones of the sample, except from group II afferents, the effects of which were found in a much smaller number of cells and may not be fully representative.