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Clinical Trial
. 2025 Jan 27:21:129-140.
doi: 10.2147/NDT.S488574. eCollection 2025.

Predictive Value of NT-proBNP for Functional Outcome of Ischemic Stroke Without Cardiac Disease: A Prospective, Observational Study

Ran Liu  1 , Guojuan Chen  2 , Na Zhao  1 , Wei Yue  1
Affiliations
Clinical Trial

Predictive Value of NT-proBNP for Functional Outcome of Ischemic Stroke Without Cardiac Disease: A Prospective, Observational Study

Ran Liu et al. Neuropsychiatr Dis Treat. .

Erratum in

Abstract

Purpose: Our study aimed to evaluate the prognostic value of NT-proBNP in predicting adverse outcomes among patients with anterior circulation infarction (ACI) and posterior circulation infarction (PCI), specifically in those without pre-existing cardiac comorbidities.

Patients and methods: This single-center, prospective observational study enrolled patients with acute ischemic stroke (AIS) within 7 days of symptom onset. We aimed to elucidate predictive role of NT-proBNP levels in determining adverse outcomes in AIS patients. Additionally, the study sought to explore the relationship between NT-proBNP levels and the risk of poor functional outcomes in both ACI and PCI patients without underlying cardiac comorbidities.

Results: A total of 821 patients were included in our study. Both univariate and multivariate logistic analyses indicated that higher NT-proBNP was an independent risk factor for adverse outcomes of ischemic stroke patients at 90 days. In noncardiogenic patients, the risks of adverse outcomes during follow-up were significantly elevated in the medium and high NT-proBNP groups (medium group: OR 1.75, 95% CI 1.03-2.98, P=0.039; high group: OR 2.46, 95% CI 1.30-4.67, P=0.006), with a dose-dependent trend. The association was similarly observed in patients with isolated ACI (medium group: OR 2.02, 95% CI 1.06-3.83, P=0.031; high group: OR 2.70, 95% CI 1.25-5.79, P=0.011). High NT-proBNP levels were independently associated with END in patients without underlying cardiac comorbidities (high group: OR 2.14, 95% CI 1.06-4.31, P=0.033) and this association was also observed in ACI patients (high group: OR 5.39, 95% CI 1.70-17.04, P=0.004). Moreover, when incorporated into the clinical prediction model, NT-proBNP exhibited excellent sensitivity and specificity for predicting stroke-related functional outcomes.

Conclusion: NT-proBNP demonstrates potential as a valuable biomarker in the clinical predictive model for functional outcomes specifically in ACI patients suggesting that elevated NT-proBNP levels in these patients should prompt closer monitoring and more comprehensive patient management.

Trial registration: https://www.chictr.org.cn/, ChiCTR2300067696.

Keywords: NT-proBNP; anterior circulation infarction; functional outcomes; posterior circulation infarction.

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Conflict of interest statement

The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Flowchart of patient inclusion.
Figure 2
Figure 2
Association between NT-proBNP and poor outcomes in cardiogenic patients.
Figure 3
Figure 3
Association between NT-proBNP and poor outcomes in noncardiogenic patients.
Figure 4
Figure 4
Association between NT-proBNP and poor outcomes in noncardiogenic patients with ACI.
Figure 5
Figure 5
Association between NT-proBNP and poor outcomes in noncardiogenic patients with PCI.
Figure 6
Figure 6
ROC curves. (A) Noncardiogenic patients; (B) Noncardiogenic patients with ACI.
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