Solar cheilosis: a comprehensive narrative review

Abstract

Solar cheilosis is a premalignant disease of the lip, typically presenting on the lower lip as a precursor to in situ squamous cell carcinoma. It is primarily caused by chronic exposure to sunlight and predominantly affects individuals with lighter skin pigmentation. This review explores solar cheilosis while providing an update on its epidemiology, etiology, pathogenesis, disease course, and other recent advancements. Specifically, we discuss the various molecular markers involved in the pathogenesis of solar cheilosis and their respective functions. Through our analysis, we aim to highlight the various clinical manifestations of solar cheilosis, emphasizing the importance of early detection, assessing risk factors, and analysis of histopathology to help confirm a diagnosis of solar cheilosis. Finally, we outline the latest available treatment modalities, ranging from conservative (non-surgical) approaches to surgical approaches. These conservative approaches include the use of laser therapy, topical agents, photodynamic therapy, and cryotherapy, while the most frequently employed surgical approach for treating solar cheilosis involves vermilionectomy.