Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2026 Feb;64(1):1512-1523.
doi: 10.1007/s10528-025-11039-w. Epub 2025 Feb 3.

Association of HindIII Polymorphism of the Lipoprotein Lipase (LPL) Gene (rs320) and Plasma Metabolic Parameters in a Nigerian Population

Joseph O Faleti  1 , Holiness S A Olasore  2 , Matthew O Olawale  1 , Abdullahi A Murtala  3 , Taiwo O Banjo  4 , Miriam N Igwo-Ezikpe  1
Affiliations

Association of HindIII Polymorphism of the Lipoprotein Lipase (LPL) Gene (rs320) and Plasma Metabolic Parameters in a Nigerian Population

Joseph O Faleti et al. Biochem Genet. 2026 Feb.

Abstract

Genetic variations in the lipoprotein lipase (LPL) gene including the HindIII polymorphism (rs320) have been reported to modify fat metabolism, adiposity, and body weight. However, little attention has been given to the African population. The present study aimed to investigate the relationship between the rs320 gene polymorphism and a number of metabolic and anthropometric parameters in a sample of the Nigerian population. We recruited 236 participants for the study. The participants were required to sign informed consent forms after which information related to their calorie intake and utilization as well as anthropometric measurements were recorded. Plasma metabolic parameters were subsequently determined using an autoanalyzer. Genotyping for HindIII polymorphism was performed using the PCR-RFLP method. The frequencies (n) of T and G alleles were 0.841 (397) and 0.158 (75), while the frequencies (n) of TT, TG, and GG were 0.691(163), 0.301(71), and 0.01(2), respectively. The population was not in Hardy-Weinberg equilibrium (χ2 = 3.717, df = 1, p = 0.841). The anthropometric parameters, the fasting blood glucose, and low-density lipoprotein cholesterol showed no association with the alleles, while plasma high-density lipoprotein cholesterol and total cholesterol were significantly higher among the G allele carriers. However, triglyceride and total protein were significantly higher among the non-G allele carriers. The LPL HindIII gene polymorphism is associated with changes in plasma lipid profile in a sample of the Nigerian population.

Keywords: Genetics; Lipid metabolism; Lipoprotein lipase; RFLP; Weight gain.

PubMed Disclaimer

Conflict of interest statement

Declarations. Conflict of interest: The authors have no conflict of interest to declare for this study.

References

    1. Ahn YI, Ferrell RE, Hamman RF, Kamboh MI (1993) Association of lipoprotein lipase gene variation with the physiological components of the insulin-resistance syndrome in the population of the San Luis Valley. Colo Diabetes Care 16(11):1502–1506 - DOI
    1. Anderson JL, King GJ, Bair TL, Elmer SP, Muhlestein JB, Habashi J, Mixson L, Carlquist JF (1999) Association of lipoprotein lipase gene polymorphisms with coronary disease. J Am Coll Cardiol 33(4):1013–1020 - DOI - PubMed
    1. Antonio G (2013) Association of LPL-HindIII polymorphism with coronary artery disease in Macedonian population. Sanamed 8(1):25–31
    1. Askari G, Heidari-Beni M, Mansourian M, Esmaeil-Motlagh M, Kelishadi R (2016) Interaction of lipoprotein lipase polymorphisms with body mass index and birth weight to modulate lipid profiles in children and adolescents: the CASPIAN-III study. Sao Paulo Med J 134(2):121–129. https://doi.org/10.1590/1516-3180.2015.00792608 . (PMID: 26786614) - DOI - PubMed - PMC
    1. Boden G, Chen X (1995) Effects of fat on glucose uptake and utilization in patients with non-insulin-dependent diabetes. J Clin Invest 96:1261–1268 - DOI - PubMed - PMC

LinkOut - more resources