Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 May:243:116203.
doi: 10.1016/j.amjsurg.2025.116203. Epub 2025 Jan 15.

Long term outcomes of gastric per oral endoscopic myotomy (GPOEM) in patients with gastroparesis

Mélissa V Wills  1 , Ayan Farah  1 , Moustafa Moussally  1 , Komol Chaivanijchaya  2 , Sol Lee  3 , Juan S Barajas-Gamboa  4 , Jerry Dang  5 , Andrew Strong  6 , Salvador Navarrete  1 , Matthew Kroh  7 , Matthew Allemang  8
Affiliations

Long term outcomes of gastric per oral endoscopic myotomy (GPOEM) in patients with gastroparesis

Mélissa V Wills et al. Am J Surg. 2025 May.

Abstract

Background: Gastroparesis often requires procedural intervention when dietary and medication therapies prove ineffective. Gastric per-oral endoscopic myotomy (G-POEM) is used to treat refractory gastroparesis, but long-term outcomes of this proceudre remain unclear.

Methods: The 100 patients from our initial study, now >6 years post-procedure from G-POEM, were contacted by phone survey for follow-up to determine clinical outcomes, including gastroparesis cardinal symptom index (GCSI). Clinical success was defined as a decrease in GCSI of ≥1.

Results: Of 30 participants, 33.3 % achieved long-term clinical success. Overall mean GCSI improved from 3.7 ​± ​0.8 to 2.8 ​± ​1.2 (p ​< ​0.01). 76.7 ​% expressed satisfaction about undergoing G-POEM. 14 patients were deceased, primarily from cardiac causes.

Conclusion: G-POEM is a safe procedure that shows promising long-term outcomes for gastroparesis symptom relief. Larger studies with more complete follow-up are needed.

PubMed Disclaimer

Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

LinkOut - more resources