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Editorial
. 2025 Feb 4;20(1):14.
doi: 10.1186/s13062-025-00608-z.

New hope for the world cancer day

Gerry Melino  1 , Julia Bischof  2 , Wen-Lian Chen  3 , Wei Jia  4 , Harmut Juhl  5 , Gelina S Kopeina  6   7 , Alessandro Mauriello  8 , Flavia Novelli  9 , Manuel Scimeca  8 , Yufang Shi  10 , Brunella Maria Pirozzi  8 , Giuseppe Sica  11 , Alexey V Zamaraev  6   7 , Boris Zhivotovsky  12   13   14
Affiliations
Editorial

New hope for the world cancer day

Gerry Melino et al. Biol Direct. .
No abstract available

Keywords: Apoptosis; Cancer; Cell death; Colorectal cancer; Fructose; Glycolysis; Immunotherapy; Metabolism; Polyol pathway; World Cancer Day.

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Conflict of interest statement

Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: Not applicable. Conflict of interest: GM, YS, GSK, FN and BZ are members of the Editorial Board of Biology Direct. The authors declare no other conflict of interest.

Figures

Fig. 1
Fig. 1
Pro-tumourigenic role of IL1 in the generation of an immune-suppressive tumour microenvironment (TME) IL-1 cytokines, particularly IL-1α and IL-1β, play a critical role in shaping the TME by promoting the recruitment and activation of immunosuppressive cells, such as tumour-associated macrophages (TAMs), regulatory T cells (Tregs), and myeloid-derived suppressor cells (MDSCs). These cells contribute to tumour progression by facilitating angiogenesis, cancer cell proliferation, migration, and immune escape
Fig. 2
Fig. 2
The Polyol pathway, involving two subsequent reactions regulated by AKR1B1 and SORD can convert glucose into fructose. Alternatively, GLUT5 receptor, encoded by SLC2A5, allows the entry of fructose into the cell. Fructolysis is able to avoid two crucial regulatory steps: Hexokinase (HK) is inhibited by its product (G-6-P) while phosphofructokinase (PFK) is inhibited by the ATP steady state levels
Fig. 3
Fig. 3
Cold ischemia is a lack of blood flow to the tissue, and this is associated with increased signal of phosphorylated extracellular signal-regulated kinase (ERK)
See this image and copyright information in PMC

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