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Review
. 2025 Feb 3;21(3):e149-e160.
doi: 10.4244/EIJ-D-24-00386.

Mechanical circulatory support for complex, high-risk percutaneous coronary intervention

Enrico G Ferro  1   2 , Joseph M Kim  1   2 , Christina Lalani  1   2 , Dawn J Abbott  3 , Robert W Yeh  1   2
Affiliations
Review

Mechanical circulatory support for complex, high-risk percutaneous coronary intervention

Enrico G Ferro et al. EuroIntervention. .

Abstract

The evidence base evaluating the use of mechanical circulatory support (MCS) devices in complex, high-risk percutaneous coronary intervention is evolving from a small number of randomised clinical trials to incorporate an amassing body of real-world data. Due to both the growing incidence of the procedures and the limitations of the evidence, there is wide variability in the use of MCS, and the benefits are actively debated. The goal of this review is to perform an integrated analysis of randomised and non-randomised studies which have informed clinical and regulatory decision-making in contemporary clinical practice. In addition, we describe forthcoming studies that have been specifically designed to advance the field and resolve ongoing controversies that remain unanswered for this complex, high-risk patient population.

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Conflict of interest statement

D.J. Abbott has received consulting fees from Abbott, Medtronic, Penumbra, and RapidAI; and research funding from Boston Scientific, MedAlliance, MicroPort, and Recor Medical. R.W. Yeh has received research funding and consulting fees from Abbott, Boston Scientific, and Medtronic; and research funding from Bard, Cook, and Philips. The other authors have no conflicts of interest relevant to the contents of this work to declare.

References

    1. Leick J, Werner N, Mangner N, Panoulas V, Aurigemma C. Optimized patient selection in high-risk protected percutaneous coronary intervention. Eur Heart J Suppl. 2022;24:J4–10. - PMC - PubMed
    1. Kunkel KJ, Dabbagh MF, Zaidan M, Alaswad K. Mechanical Circulatory Support in High-Risk Percutaneous Coronary Intervention. Interv Cardiol Clin. 2021;10:207–19. - PubMed
    1. Truesdell AG, Davies R, Eltelbany M, Megaly M, Rosner C, Cilia LA. Mechanical Circulatory Support for Complex High-risk Percutaneous Coronary Intervention. US Cardiol. 2023;17:e03. - PMC - PubMed
    1. Pavlidis AN, Perera D, Karamasis GV, Bapat V, Young C, Clapp BR, Blauth C, Roxburgh J, Thomas MR, Redwood SR. Implementation and consistency of Heart Team decision-making in complex coronary revascularisation. Int J Cardiol. 2016;206:37–41. - PubMed
    1. Writing Committee Members Lawton JS, Tamis-Holland JE, Bangalore S, Bates ER, Beckie TM, Bischoff JM, Bittl JA, Cohen MG, DiMaio JM, Don CW, Fremes SE, Gaudino MF, Goldberger ZD, Grant MC, Jaswal JB, Kurlansky PA, Mehran R, Metkus TS Jr, Nnacheta LC, Rao SV, Sellke FW, Sharma G, Yong CM, Zwischenberger BA. 2021 ACC/AHA/SCAI Guideline for Coronary Artery Revascularization: Executive Summary: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. J Am Coll Cardiol. 2022;79:197–215. - PubMed

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