Evidence-based Korean guidelines for the clinical management of multiple myeloma: addressing 12 key clinical questions

Sung-Hoon Jung¹, Youngil Koh², Min Kyoung Kim³, Jin Seok Kim⁴, Joon Ho Moon⁵, Chang-Ki Min⁶, Dok Hyun Yoon⁷, Sung-Soo Yoon², Je-Jung Lee¹, Chae Moon Hong⁸, Ka-Won Kang⁹, Jihyun Kwon¹⁰, Kyoung Ha Kim¹¹, Dae Sik Kim¹², Sung Yong Kim¹³, Sung-Hyun Kim¹⁴, Yu Ri Kim⁴, Young Rok Do¹⁵, Yeung-Chul Mun¹⁶, Sung-Soo Park⁶, Young Hoon Park¹⁶, Ho Jin Shin¹⁷, Hyeon-Seok Eom¹⁸, Sang Eun Yoon¹⁹, Sang Mee Hwang²⁰, Won Sik Lee²¹, Myung-Won Lee²², Jun Ho Yi²³, Ji Yun Lee²⁴, Ji Hyun Lee¹⁴, Ho Sup Lee²⁵, Sung-Nam Lim²⁶, Jihyang Lim²⁷, Ho-Young Yhim²⁸, Yoon Hwan Chang²⁹, Jae-Cheol Jo³⁰, Jinhyun Cho³¹, Hyungwoo Cho⁷, Yoon Seok Choi⁹, Hee Jeong Cho⁵, Ari Ahn³², Jong Han Choi³³, Hyun Jung Kim³⁴, Kihyun Kim³⁵

Affiliations

¹ Department of Hematology-Oncology, Chonnam National University Hwasun Hospital, Chonnam National University Medical School, Hwasun, Republic of Korea.
² Division of Hematology-Oncology, Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.
³ Division of Hemato-Oncology, Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, Republic of Korea.
⁴ Division of Hematology, Department of Internal Medicine, Yonsei University College of Medicine, Severance Hospital, Seoul, Republic of Korea.
⁵ Department of Hematology/Oncology, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
⁶ Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
⁷ Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
⁸ Department of Nuclear Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
⁹ Division of Hematology-Oncology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea.
¹⁰ Department of Internal Medicine, Hematology and Oncology, College of Medicine, Chungbuk National University, Cheongju, Republic of Korea.
¹¹ Division of Hematology and Oncology, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Seoul, Republic of Korea.
¹² Division of Oncology & Hematology, Department of Internal Medicine, Korea University Guro Hospital, Seoul, Republic of Korea.
¹³ Hematology & Oncology, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Republic of Korea.
¹⁴ Division of Hematology-Oncology, Department of Internal Medicine, Dong-A University College of Medicine, Busan, Republic of Korea.
¹⁵ Division of Hematology-Oncology, Department of Internal Medicine, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Republic of Korea.
¹⁶ Department of Internal Medicine, Ewha Womans University College of Medicine, Seoul, Republic of Korea.
¹⁷ Division of Hematology-Oncology, Department of Internal Medicine, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Republic of Korea.
¹⁸ Department of Hematology-Oncology, Center for Hematologic Malignancy, National Cancer Center, Goyang, Republic of Korea.
¹⁹ Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-Ro, Gangnam-Gu, Seoul, Republic of Korea.
²⁰ Department of Laboratory Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea.
²¹ Department of Internal Medicine, Hematology, Inje University Busan Paik Hospital, Busan, Republic of Korea.
²² Division of Hematology and Oncology, Department of Internal Medicine, Chungnam National University Hospital, Daejeon, Republic of Korea.
²³ Division of Hematology-Oncology, Department of Medicine, Chung-Ang University, Seoul, Republic of Korea.
²⁴ Division of Hematology and Medical Oncology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea.
²⁵ Department of Internal Medicine, Kosin University College of Medicine, Kosin University Gospel Hospital, Busan, Republic of Korea.
²⁶ Department of Internal Medicine, Inje University College of Medicine, Haeundae Paik Hospital, Busan, Republic of Korea.
²⁷ Department of Laboratory Medicine, Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
²⁸ Department of Internal Medicine, Jeonbuk National University Medical School, Jeonju, Republic of Korea.
²⁹ Department of Laboratory Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.
³⁰ Department of Hematology and Oncology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Republic of Korea.
³¹ Division of Hematology-Oncology, Department of Internal Medicine, Inha University Hospital, Inha University School of Medicine, Incheon, Republic of Korea.
³² Department of Laboratory Medicine, College of Medicine, Incheon St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea.
³³ Department of Endocrine and Metabolism Medicine, Konkuk University Medical Center, Seoul, Republic of Korea.
³⁴ Institute for Evidence-Based Medicine, Cochrane Korea College of Medicine, Korea University, Seoul, Republic of Korea.
³⁵ Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-Ro, Gangnam-Gu, Seoul, Republic of Korea. kihyunkimk@gmail.com.

PMID: 39903326
PMCID: PMC11794900
DOI: 10.1007/s44313-025-00055-9

Review

Evidence-based Korean guidelines for the clinical management of multiple myeloma: addressing 12 key clinical questions

Sung-Hoon Jung et al. Blood Res. 2025.

. 2025 Feb 4;60(1):9.

doi: 10.1007/s44313-025-00055-9.

Authors

Affiliations

¹ Department of Hematology-Oncology, Chonnam National University Hwasun Hospital, Chonnam National University Medical School, Hwasun, Republic of Korea.
² Division of Hematology-Oncology, Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.
³ Division of Hemato-Oncology, Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, Republic of Korea.
⁴ Division of Hematology, Department of Internal Medicine, Yonsei University College of Medicine, Severance Hospital, Seoul, Republic of Korea.
⁵ Department of Hematology/Oncology, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
⁶ Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
⁷ Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
⁸ Department of Nuclear Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
⁹ Division of Hematology-Oncology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea.
¹⁰ Department of Internal Medicine, Hematology and Oncology, College of Medicine, Chungbuk National University, Cheongju, Republic of Korea.
¹¹ Division of Hematology and Oncology, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Seoul, Republic of Korea.
¹² Division of Oncology & Hematology, Department of Internal Medicine, Korea University Guro Hospital, Seoul, Republic of Korea.
¹³ Hematology & Oncology, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Republic of Korea.
¹⁴ Division of Hematology-Oncology, Department of Internal Medicine, Dong-A University College of Medicine, Busan, Republic of Korea.
¹⁵ Division of Hematology-Oncology, Department of Internal Medicine, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Republic of Korea.
¹⁶ Department of Internal Medicine, Ewha Womans University College of Medicine, Seoul, Republic of Korea.
¹⁷ Division of Hematology-Oncology, Department of Internal Medicine, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Republic of Korea.
¹⁸ Department of Hematology-Oncology, Center for Hematologic Malignancy, National Cancer Center, Goyang, Republic of Korea.
¹⁹ Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-Ro, Gangnam-Gu, Seoul, Republic of Korea.
²⁰ Department of Laboratory Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea.
²¹ Department of Internal Medicine, Hematology, Inje University Busan Paik Hospital, Busan, Republic of Korea.
²² Division of Hematology and Oncology, Department of Internal Medicine, Chungnam National University Hospital, Daejeon, Republic of Korea.
²³ Division of Hematology-Oncology, Department of Medicine, Chung-Ang University, Seoul, Republic of Korea.
²⁴ Division of Hematology and Medical Oncology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea.
²⁵ Department of Internal Medicine, Kosin University College of Medicine, Kosin University Gospel Hospital, Busan, Republic of Korea.
²⁶ Department of Internal Medicine, Inje University College of Medicine, Haeundae Paik Hospital, Busan, Republic of Korea.
²⁷ Department of Laboratory Medicine, Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
²⁸ Department of Internal Medicine, Jeonbuk National University Medical School, Jeonju, Republic of Korea.
²⁹ Department of Laboratory Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.
³⁰ Department of Hematology and Oncology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Republic of Korea.
³¹ Division of Hematology-Oncology, Department of Internal Medicine, Inha University Hospital, Inha University School of Medicine, Incheon, Republic of Korea.
³² Department of Laboratory Medicine, College of Medicine, Incheon St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea.
³³ Department of Endocrine and Metabolism Medicine, Konkuk University Medical Center, Seoul, Republic of Korea.
³⁴ Institute for Evidence-Based Medicine, Cochrane Korea College of Medicine, Korea University, Seoul, Republic of Korea.
³⁵ Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-Ro, Gangnam-Gu, Seoul, Republic of Korea. kihyunkimk@gmail.com.

PMID: 39903326
PMCID: PMC11794900
DOI: 10.1007/s44313-025-00055-9

Erratum in

Correction: Evidence‑based Korean guidelines for the clinical management of multiple myeloma: addressing 12 key clinical questions.
Jung SH, Koh Y, Kim MK, Kim JS, Moon JH, Min CK, Yoon DH, Yoon SS, Lee JJ, Hong CM, Kang KW, Kwon J, Kim KH, Kim DS, Kim SY, Kim SH, Kim YR, Do YR, Mun YC, Park SS, Park YH, Shin HJ, Eom HS, Yoon SE, Hwang SM, Lee WS, Lee MW, Yi JH, Lee JY, Lee JH, Lee HS, Lim SN, Lim J, Yhim HY, Chang YH, Jo JC, Cho J, Cho H, Choi YS, Cho HJ, Ahn A, Choi JH, Kim HJ, Kim K. Jung SH, et al. Blood Res. 2025 Apr 8;60(1):23. doi: 10.1007/s44313-025-00074-6. Blood Res. 2025. PMID: 40198482 Free PMC article. No abstract available.

Abstract

Multiple myeloma (MM), a hematological malignancy, is characterized by malignant plasma cell proliferation in the bone marrow. Recent treatment advances have significantly improved patient outcomes associated with MM. In this study, we aimed to develop comprehensive, evidence-based guidelines for the diagnosis, prognosis, and treatment of MM. We identified 12 key clinical questions essential for MM management, guiding the extensive literature review and meta-analysis of the study. Our guidelines provide evidence-based recommendations by integrating patient preferences with survey data. These recommendations include current and emerging diagnostic tools, therapeutic agents, and treatment strategies. By prioritizing a patient-centered approach and rigorous data analysis, these guidelines were developed to enhance MM management, both in Korea and globally.

Keywords: Guidelines; Meta-analysis; Multiple myeloma; Prognosis; Treatment.

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Conflict of interest statement

Declarations. Ethics approval and consent to participate: Not applicable. Competing interests: The authors declare no competing interests.

References

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Evidence-based Korean guidelines for the clinical management of multiple myeloma: addressing 12 key clinical questions

Affiliations

Evidence-based Korean guidelines for the clinical management of multiple myeloma: addressing 12 key clinical questions

Authors

Affiliations

Erratum in

Abstract

Conflict of interest statement

References

Publication types

LinkOut - more resources

Full Text Sources