Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Mar;22(1):5-10.
doi: 10.1007/s10393-025-01700-6. Epub 2025 Feb 4.

Identification of Distinct Rodent-Associated Adenovirus Lineages from Mixed-Use Landscape

B R Ansil  1 , Avirup Sanyal  1   2 , Darshan Sreenivas  1 , Kritika M Garg  3   4 , Uma Ramakrishnan  1 , Balaji Chattopadhyay  5   6
Affiliations

Identification of Distinct Rodent-Associated Adenovirus Lineages from Mixed-Use Landscape

B R Ansil et al. Ecohealth. 2025 Mar.

Abstract

Land-use change and increased human-livestock-wildlife interactions have generated numerous possibilities for viral spillover, demanding enhanced surveillance in biodiverse regions. We investigated adenovirus diversity in small mammals, an understudied host taxon, from a forest-plantation mosaic in the Western Ghats biodiversity hotspot. We observed high prevalence (up to 39.39%) and identified five lineages of adenoviruses with unique mutations in the dominant small mammal species, Rattus satarae. These lineages significantly differed from other known murine adenoviruses (p-distance > 25%), indicating the likelihood of novel adenoviruses in this endemic small mammal and suggesting potential for unexplored DNA virus diversity in the region.

Keywords: DNA viruses; India; small mammals; surveillance.

PubMed Disclaimer

Similar articles

See all similar articles

References

    1. Allen T, Murray KA, Zambrana-Torrelio C, Morse SS, Rondinini C, Di Marco M, Breit N, Olival KJ, Daszak P (2017) Global hotspots and correlates of emerging zoonotic diseases. Nature Communications 8(1):1124. https://doi.org/10.1038/s41467-017-00923-8 - DOI - PubMed - PMC
    1. Ansil BR, Mendenhall IH, Ramakrishnan U (2021) High prevalence and diversity of Bartonella in small mammals from the biodiverse Western Ghats. PLOS Neglected Tropical Diseases 15(3):e0009178. https://doi.org/10.1371/journal.pntd.0009178 - DOI - PubMed - PMC
    1. Borkenhagen LK, Fieldhouse JK, Seto D, Gray GC (2019) Are adenoviruses zoonotic? A systematic review of the evidence. Emerging Microbes & Infections 8(1):1679–1687. https://doi.org/10.1080/22221751.2019.1690953 - DOI
    1. Borremans B, Faust C, Manlove KR, Sokolow SH, Lloyd-Smith JO (2019) Cross-species pathogen spillover across ecosystem boundaries: Mechanisms and theory. Philosophical Transactions of the Royal Society B 374(1782):20180344. https://doi.org/10.1098/rstb.2018.0344 - DOI
    1. Chitradevi S, Sukumar K, Suresh P, Balasubramaniam GA, Kannan D (2021) Molecular typing and pathogenicity assessment of fowl adenovirus associated with inclusion body hepatitis in chicken from India. Tropical Animal Health and Production 53(4):412. https://doi.org/10.1007/s11250-021-02851-8 - DOI - PubMed

LinkOut - more resources