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. 2025 Mar;22(1):5-10.
doi: 10.1007/s10393-025-01700-6. Epub 2025 Feb 4.

Identification of Distinct Rodent-Associated Adenovirus Lineages from Mixed-Use Landscape

B R Ansil  1 , Avirup Sanyal  1   2 , Darshan Sreenivas  1 , Kritika M Garg  3   4 , Uma Ramakrishnan  1 , Balaji Chattopadhyay  5   6
Affiliations

Identification of Distinct Rodent-Associated Adenovirus Lineages from Mixed-Use Landscape

B R Ansil et al. Ecohealth. 2025 Mar.

Abstract

Land-use change and increased human-livestock-wildlife interactions have generated numerous possibilities for viral spillover, demanding enhanced surveillance in biodiverse regions. We investigated adenovirus diversity in small mammals, an understudied host taxon, from a forest-plantation mosaic in the Western Ghats biodiversity hotspot. We observed high prevalence (up to 39.39%) and identified five lineages of adenoviruses with unique mutations in the dominant small mammal species, Rattus satarae. These lineages significantly differed from other known murine adenoviruses (p-distance > 25%), indicating the likelihood of novel adenoviruses in this endemic small mammal and suggesting potential for unexplored DNA virus diversity in the region.

Keywords: DNA viruses; India; small mammals; surveillance.

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