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Review
. 2025 Mar:80:101637.
doi: 10.1016/j.ghir.2025.101637. Epub 2025 Jan 23.

Cellular senescence and PAPP-A

Cheryl A Conover  1
Affiliations
Review

Cellular senescence and PAPP-A

Cheryl A Conover. Growth Horm IGF Res. 2025 Mar.

Abstract

Cellular senescence and its accompanying secretome have major impact on growth and aging of mammalian organisms. A novel protease, PAPP-A, regulates the bioavailability of an important growth factor, insulin-like growth factor (IGF)-I, and has major impact on growth and aging. This short review will explore a new perspective of cellular senescence and PAPP-A.

Keywords: Cellular senescence; Insulin-like growth factor; PAPP-A; SASP.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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