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Review
. 2024 Dec 27:14:100559.
doi: 10.1016/j.ijregi.2024.100559. eCollection 2025 Mar.

Pertussis in Southeast Asia: country-level burden and recommendations from the Global Pertussis Initiative

Phung Nguyen The Nguyen  1 , Ulrich Heininger  2 , Rudzani Muloiwa  3 , Carl Heinz Wirsing von König  4 , Daniela Hozbor  5 , Anna Ong-Lim  6 , Tina Q Tan  7 , Kevin Forsyth  8 ; Global Pertussis Initiative Southeast Asia Network
Affiliations
Review

Pertussis in Southeast Asia: country-level burden and recommendations from the Global Pertussis Initiative

Phung Nguyen The Nguyen et al. IJID Reg. .

Abstract

The Global Pertussis Initiative met in March 2024 to discuss the burden of pertussis and prevention efforts in six Southeast Asian countries: Cambodia, Indonesia, Malaysia, Singapore, Thailand, and Vietnam. Except for Cambodia, pertussis is a notifiable disease; data accuracy varies within and between countries. Most cases in the region are diagnosed based on clinical suspicion. Whole-cell and acellular pertussis combination vaccines are available, but the composition differs between countries. Immunization against pertussis is well-established, but policies regarding boosting vary. Vaccination in pregnancy represents a still-neglected opportunity to protect infants. The Global Pertussis Initiative recommends enacting vaccination in pregnancy in countries without and increasing coverage in countries with policies already in place. There is a need to correct the misperception that pertussis affects children exclusively and that childhood vaccines provide lifelong protection. Education is key to widespread understanding of the threat of pertussis and removing barriers to vaccination in Southeast Asia.

Keywords: Global Pertussis Initiative; Immunization; Pertussis; Southeast Asia; Surveillance; Vaccine.

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Conflict of interest statement

The authors are scientific experts and, as such, received honoraria for their participation in this live meeting from Sanofi. In addition, U.H. was a member of the Collaboration of European Experts on Pertussis Awareness Generation (CEEPAG; he was a group member until 2021) and has received honoraria for participation in previously associated live meetings from Sanofi, USA, and Sanofi, France, respectively, as well as receiving honoraria for educational activities from GSK, Pfizer, MSD, Sanofi, and InfectoPharm. R.M. has received honoraria for educational activities from MSD and Sanofi. C.H.W.K. has received honoraria for attending meetings sponsored by Sanofi, GSK Biologicals SA, MSD, and Novartis Vaccines. T.Q.T. has received grants from Merck and Sanofi, personal fees from GSK Biologicals and Sanofi, and honoraria from Sanofi. K.F. has also previously received honoraria from Sanofi. The authors declare no other conflict of interest.

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