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. 2024 Dec 1:21:45.
doi: 10.18502/fid.v21i45.17178. eCollection 2024.

Antifungal Efficacy of Ganoderma lucidum and Clotrimazole for Treatment of Denture Stomatitis: A Randomized Clinical Trial

Fahimeh Pakravan  1 , Afsaneh Yegdaneh  2 , Somayeh Taymouri  3 , Shiva Rahimi  4 , Negin Ghahremani  4
Affiliations

Antifungal Efficacy of Ganoderma lucidum and Clotrimazole for Treatment of Denture Stomatitis: A Randomized Clinical Trial

Fahimeh Pakravan et al. Front Dent. .

Abstract

Objectives: This study aimed to compare the antifungal efficacy of Ganoderma lucidum (G. lucidum) and clotrimazole for treatment of denture stomatitis (DS). Materials and Methods: This double-blind randomized clinical trial was conducted on 50 patients with DS types I and II assigned to two groups (N=25). In the first group, G. lucidum extract was administered in the form of 5% gel while 1% clotrimazole gel was prescribed for the second group. Pain intensity according to the visual analog scale (VAS), and the percentage of DS recovery based on the Budtz-Jorgenson index were evaluated and recorded after 7 and 14 days. Data were analyzed using the Chi-square test, independent samples t-test, repeated measures ANOVA, and logistic regression (alpha=0.05). Results: The percentage of complete recovery on day 7 in the G. lucidum group (28%) was higher than that in the clotrimazole group (16%) but not significantly (P=0.592). Not wearing dentures overnight significantly increased the odds of recovery by 6.56 times, while the odds of recovery decreased by 0.03 times in DS type II, as compared to DS type I (P= 0.009). Conclusion: No significant difference existed between the antifungal efficacy of G. lucidum and clotrimazole for clinical treatment of DS. Thus, Ganoderma may be regarded as an alternative treatment, especially in patients' resistant to azoles. Nonetheless, further clinical studies are required to shed more light on this topic.

Keywords: Antifungal Agents; Clotrimazole; Reishi.

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Conflict of interest statement

None declared.

Figures

Fig. 1
Fig. 1
Consort flow-diagram of patient selection and allocation
Fig. 2
Fig. 2
Frequency of patients’ recovery at 7 and 14 days after the intervention in the two groups
See this image and copyright information in PMC

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