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. 2025 Jan 5;17(1):e76943.
doi: 10.7759/cureus.76943. eCollection 2025 Jan.

Short-Term Outcomes of Laparoscopic Sleeve Gastrectomy for Weight Loss and Gastroesophageal Reflux Disease

Mian S Yousaf  1 , Noman Khan  2 , Ghulam Fareed  3 , Arbab M Kashif Khan  4   1 , Saad Aziz  5 , Masood M Karim  6
Affiliations

Short-Term Outcomes of Laparoscopic Sleeve Gastrectomy for Weight Loss and Gastroesophageal Reflux Disease

Mian S Yousaf et al. Cureus. .

Abstract

Background and objective Laparoscopic sleeve gastrectomy (LSG), a novel bariatric technique, reduces stomach capacity to promote weight loss. It is increasingly preferred due to its lower risk and improved outcomes, particularly for obesity-associated hypertension and diabetes. LSG has also demonstrated effective weight loss. This study aimed to evaluate the short-term outcomes of LSG for treating obesity and gastroesophageal reflux disease (GERD). Methodology A prospective cohort study was conducted at Lady Reading Hospital-Medical Teaching Institute (LRH-MTI), Peshawar, from March 2023 to February 2024. A total of 280 patients (aged 18-60 years) were selected using a consecutive sampling technique. Weight loss was assessed using the percentage of total body weight loss (%TBWL) and excess weight loss (%EWL). GERD symptoms were evaluated using the GerdQ score. Statistical analyses, including paired t-tests and Chi-squared tests, were performed using SPSS version 26 (IBM Inc., Armonk, New York), with significance set at p<0.05. Results LSG achieved a 100% success rate with no major complications, an average surgery duration of 45 minutes, and a mean hospital stay of 2.5 days. At the 12-month follow-up, significant reductions in hypertension (p=0.032) and diabetes (p<0.012) were observed. Substantial weight loss (p=0.001) and a decrease in comorbidities were noted, while GERD symptom improvement was not statistically significant (p=0.348). Conclusion LSG is a promising intervention for weight loss and obesity-related comorbidities. It significantly improves hypertension and diabetes, although its impact on GERD requires further research. Longer follow-ups and diverse populations are recommended for future studies.

Keywords: bariatric surgery; comorbidities; gastroesophageal reflux disease; laparoscopic sleeve gastrectomy; obesity; weight loss.

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Conflict of interest statement

Human subjects: Consent for treatment and open access publication was obtained or waived by all participants in this study. Institutional Review Board (IRB) of Lady Reading Hospital-Medical Teaching Institute (LRH-MTI), Peshawar issued approval 77/LRH/MTI. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

Figures

Figure 1
Figure 1. A graph illustrating a notable reduction in the prevalence of hypertension and diabetes at the 12-month follow-up
Figure 2
Figure 2. Snapshot of the IRB approval letter
See this image and copyright information in PMC

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