Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Mar 12;32(1):1-8.
doi: 10.1159/000537685. eCollection 2025 Feb.

Prevalence of Endoscopic and Histological Lesions at Upper Endoscopy: A Cross-Sectional, Multicentre Study in Clinical Practice

Vincenzo De Francesco  1 , Angelo Zullo  2 , Arnaldo Amato  3 , Irene Bergna  3 , Emanuele Bendia  4 , Giorgia Giorgini  4 , Elisabetta Buscarini  5 , Guido Manfredi  5 , Sergio Cadoni  6 , Renato Cannizzaro  7 , Stefano Realdon  7 , Mario Ciuffi  8 , Orazio Ignomirelli  8 , Paola Da Massa Carrara  9 , Giovanni Finucci  9 , Antonietta Di Somma  10 , Chiara Frandina  11 , Mariafrancesca Loria  11 , Francesca Galeazzi  12 , Francesco Ferrara  12 , Carlo Gemme  13 , Noemi Sara Bertetti  13 , Federica Gentili  14 , Antonio Lotito  14 , Bastianello Germanà  15 , Nunzia Russo  15 , Giuseppe Grande  16 , Rita Conigliaro  16 , Federico Cravero  17 , Giovanna Venezia  17 , Riccardo Marmo  18 , Piera Senneca  18 , Angelo Milano  19 , Konstantinos Efthymakis  19 , Fabio Monica  10   20 , Paolo Montalto  21 , Mario Lombardi  21 , Olivia Morelli  22 , Danilo Castellani  22 , Daniela Nigro  23 , Roberto Festa  23 , Sergio Peralta  24 , Maria Grasso  24 , Antonino Carlo Privitera  25 , Maria Emanuela Di Stefano  25 , Giuseppe Scaccianoce  26 , Mariangela Loiacono  26 , Sergio Segato  27 , Marco Balzarini  27 , Paolo Usai Satta  28 , Mariantonia Lai  28 , Raffaele Manta  9
Affiliations

Prevalence of Endoscopic and Histological Lesions at Upper Endoscopy: A Cross-Sectional, Multicentre Study in Clinical Practice

Vincenzo De Francesco et al. GE Port J Gastroenterol. .

Erratum in

  • Erratum.
    [No authors listed] [No authors listed] GE Port J Gastroenterol. 2025 Apr 7;32(5):379-380. doi: 10.1159/000544848. eCollection 2025 Oct. GE Port J Gastroenterol. 2025. PMID: 41090145 Free PMC article.

Abstract
in English, Portuguese

Background/aim: Prevalence of gastroduodenal endoscopic and histological lesions may modify over time due to different factors. We assessed both macroscopic and histological lesions currently detected at upper endoscopy performed in routine practice.

Patients and methods: Clinical, endoscopic, and histological data of consecutive adult patients referred for upper endoscopy in the 28 participating centres were analysed. Only patients who underwent the first endoscopic examination were considered. Prevalence of erosive/ulcerative lesions, cancers and extensive precancerous lesions in the stomach, and Helicobacter pylori infection was computed.

Results: A total of 1,431 patients underwent endoscopy for gastro-oesophageal reflux symptoms (31.5%), dyspepsia (29.4%), or alarm symptoms (18.5%). Erosive oesophagitis or Barrett's oesophagus was detected in 210 (14.7%) cases, peptic ulcer in 49 (3.4%), and a neoplastic lesion in 17 (1.2%). H. pylori was present in 201 (22.6%) cases, and extensive precancerous lesions on gastric mucosa in 46 (5.6%) patients. Gastric lesions were more prevalent in patients aged ≥50 years (26% vs. 18%; p = 0.001), and peptic ulcers were more frequently detected in patients with H. pylori (9.4% vs. 2.3%; p = 0.001) and in males (5.8% vs. 1.6%; p = 0.001), while neoplastic lesions in patients with alarm symptoms (3.8% vs. 0.6%; p = 0.001).

Conclusions: The overall endoscopic lesions were more prevalent in patients aged ≥50 years, peptic ulcer and erosions were more frequent in H. pylori-infected patients, and extensive gastric precancerous lesions were present in less than 6% of cases.

Introdução/objetivo: A prevalência de lesões endoscópicas e histológicas gastroduodenais pode modificar-se ao longo do tempo devido a alterações de diferentes fatores. Este estudo teve como objetivo avaliar lesões macroscópicas e histológicas e detectadas na esofagogastroduodenoscopia realizada na prática rotineira.

Pacientes e métodos: Foram analisados dados clínicos, endoscópicos e histológicos de pacientes adultos consecutivos encaminhados para esofagogastroduodenoscopia nos 28 centros participantes. Foram considerados apenas os pacientes que realizaram o primeiro endoscopia. Foi computada a prevalência de lesões erosivas/ulcerativas, cânceres e lesões pré-cancerosas difusas no estômago e infecção por H. pylori.

Resultados: Um total de 1,431 pacientes foram submetidos à endoscopia foram sintomas de refluxo gastroesofágico (31.5%), dispepsia (29.4%) e sintomas de alarme (18.5%). Esofagite erosiva ou esôfago de Barrett foram detectadas em 210 (14.7%) casos, úlcera péptica em 49 (3.4%), lesão neoplásica em 17 (1.2%). A infecção por H. pylori esteve presente em 201 (22.6%) casos, lesões gastricas pré-cancerosas difusas em 46 (5.6%). As lesões endoscópicas foram mais prevalentes em pacientes com idade ≥50 anos (26% vs. 18%; p = 0.001), com úlceras pépticas detectadas com mais frequência em pacientes com H. pylori (9.4% vs. 2.3%; p = 0.001) e no sexo masculino (5.8% vs. 1.6%; p = 0.001), enquanto lesões neoplásicas naqueles que apresentam sintomas de alarme (3.8% vs. 0.6%; p = 0.001).

Conclusões: As lesões endoscópicas globais foram mais prevalentes em pacientes com idade >50 anos, úlcera péptica e erosões foram mais frequentes em pacientes infectados por H. pylori. Lesoes gástricas pre-cancerosas estiveram presentes em menos de 6% dos casos.

Keywords: Cancer; Helicobacter pylori; Peptic ulcer; Precancerous lesions; Upper endoscopy.

PubMed Disclaimer

Conflict of interest statement

The authors have no conflicts of interest to declare.

References

    1. Li Y, Choi H, Leung K, Jiang F, Graham DY, Leung WK. Global prevalence of Helicobacter pylori infection between 1980 and 2022: a systematic review and meta-analysis. Lancet Gastroenterol Hepatol. 2023;8(6):553–64. - PubMed
    1. O’Connor HJ. Forty years of Helicobacter pylori infection and changes in findings at esophagogastroduodenoscopy. Helicobacter. 2023;28(6):e13026. - PubMed
    1. De Francesco V, Manta R, Marmo R, Marmo C, Rago A, Antonelli G, et al. Efficacy of Helicobater pylori eradication in patients with diffuse large B-cell lymphoma of the stomach: a systematic review. Eur J Haematol. 2022;109(6):643–7. - PubMed
    1. Jahid M, Khan KU, Rehan-Ul-Haq, Ahmed RS. Overview of rheumatoid arthritis and scientific understanding of the disease. Mediterr J Rheumatol. 2023;34(3):284–91. - PMC - PubMed
    1. Patel NP, Bates CM, Patel A. Developmental approaches to chronic pain: a narrative review. Cureus. 2023;15(9):e45238. - PMC - PubMed

LinkOut - more resources