Three-dimensional structure of calmodulin
- PMID: 3990807
- DOI: 10.1038/315037a0
Three-dimensional structure of calmodulin
Abstract
The three-dimensional structure of calmodulin has been determined crystallographically at 3.0 A resolution. The molecule consists of two globular lobes connected by a long exposed alpha-helix. Each lobe binds two calcium ions through helix-loop-helix domains similar to those of other calcium-binding proteins. The long helix between the lobes may be involved in interactions of calmodulin with drugs and various proteins.
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