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. 2025 Jun 1;110(6):1417-1421.
doi: 10.3324/haematol.2024.286973. Epub 2025 Feb 6.

Multinational cohort study of intracranial hemorrhage in patients with brain metastases receiving anticoagulation

Eva N Hamulyák  1 , Tzu-Fei Wang  2 , Lisa Baumann Kreuziger  3 , Varun Iyengar  4 , Brian J Carney  5 , Ann Hoeben  6 , Berna C Özdemir  7 , Rosana D Cordova Serrano  8 , Kristen M Sanfilippo  9 , Shira Rozenblatt  10 , Ludo F M Beenen  11 , Shlomit Yust-Katz  12 , Erez Halperin  13 , Ariela Arad  14 , Aharon Lubetsky  15 , Marc Carrier  2 , Benjamin Massat  16 , Harry R Büller  1 , Galia Spectre  13 , Jeffrey I Zwicker  17 , Avi Leader  18 , Abc Study Group  19
Affiliations

Multinational cohort study of intracranial hemorrhage in patients with brain metastases receiving anticoagulation

Eva N Hamulyák et al. Haematologica. .
No abstract available

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Figures

Figure 1.
Figure 1.
12-month cumulative incidence of intracranial hemorrhage. Cumulative incidence of any intracranial hemorrhage (ICH) (A), major ICH (B) with direct oral anticoagulant DOAC (blue curve) or low-molecular-weight heparin (LMWH) (red curve) treatment. The shaded areas represent the 95% Confidence Interval. Major ICH was defined as volume ≥10 mL OR surgical intervention OR clinical symptoms, focal neurologic deficits or cognitive changes. Overt ICH was defined as any ICH excluding hemosiderin deposits and/or trace/unmeasurable ICH (indicative of prior intra/extra-tumoral hemorrhage).
Figure 2.
Figure 2.
Clinical presentation and course of any anticoagulation-associated intracranial hemorrhage. Severity of hemorrhage by percentage of patients at clinical presentation (A) and clinical course (B) of any spontaneous intracranial hemorrhage (ICH) in patients experiencing ICH while on direct oral anticoagulant (DOAC) (N=22) compared to those on low-molecular-weight heparin (LMWH) (N=20). Clinical severity of ICH was assessed using pre-specified criteria. None of the patients presented with an ICH event of category 4.
See this image and copyright information in PMC

References

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