Update on long-term outcomes of a cohort of patients with TCF3::HLF-positive acute lymphoblastic leukemia treated with blinatumomab and stem cell transplantation

Aida Zeckanovic¹, Brice Mouttet², Luciana Vinti³, Philip Ancliff⁴, Benoît Brethon⁵, Gunnar Cario⁶, Sarah Elitzur⁷, Volkan Hazar⁸, Joachim Kunz⁹, Anja Möricke⁶, Jerry Stein¹⁰, Yöntem Yaman¹¹, Jochen Buechner¹², Magnus Aasved Hjort¹³, David O'Connor⁴, Angus Hodder¹⁴, Jack Bartram⁴, Julia Alten¹⁵, Draga Barbaric¹⁶, Gabriele Escherich¹⁷, Nicolas Boissel¹⁸, Loïc Vasseur¹⁸, Emmanuelle Clappier¹⁹, Laure Farnault²⁰, Sarah Bonnet²¹, Katharine Patrick²², Martin Schrappe⁶, Sema Anak⁸, André Baruchel⁵, Franco Locatelli³, Martin Stanulla²³, Arend Von Stackelberg²⁴, Nicole Bodmer¹, Jean-Pierre Bourquin²⁵

Affiliations

¹ Pediatric Oncology, University Children's Hospital Zurich, Zurich.
² The Kaiya Foundation for Children with Very High Risk Leukemia, London.
³ Department of Pediatric Haemato-Oncology, IRCCS Ospedale Bambino Gesù, Roma, Catholic University of the Sacred Heart, Rome.
⁴ Department of Haematology, Great Ormond Street Hospital, London.
⁵ Department of Pediatric Hematology, Hôpital Robert Debré, Assistance Publique-Hôpitaux de Paris, Paris.
⁶ Department of Pediatrics I, ALL-BFM Study Group, Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein, Kiel.
⁷ Pediatric Hematology-Oncology, Schneider Children's Medical Center, Sackler Faculty of Medicine, Aviv University.
⁸ Department of Pediatric Oncology, Memorial Health Care, Private Medstar Yildiz Hospital, Antalya.
⁹ Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Heidelberg.
¹⁰ Bone Marrow Transplant Unit, Schneider Children's Medical Center, Sackler Faculty of Medicine, Aviv University.
¹¹ Department of Pediatric Hematology, Medipol University Hospital, İstanbul.
¹² Department of Pediatric Hematology and Oncology, Oslo University Hospital, Oslo.
¹³ Department of Paediatric Haematology and Oncology, St. Olav's University Hospital, Trondheim.
¹⁴ University College London Hospitals NHS Foundation Trust, London.
¹⁵ Laboratory of Cytogenetics and Molecular Genetics, ALL-BFM Study Group, Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein, Kiel.
¹⁶ School of Clinical Medicine, UNSW Sydney, Sydney, NSW, Australia; Kids Cancer Centre, Sydney Children's Hospital, Randwick, NSW 2031.
¹⁷ Clinic for Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf.
¹⁸ Adolescent and Young Adult Hematology Unit, Saint Louis University Hospital, Assistance Publique-Hôpitaux de Paris, Paris.
¹⁹ Hematology Laboratory, Saint Louis University Hospital, Assistance Publique-Hôpitaux de Paris, Paris.
²⁰ Hematology and Cellular Therapy Department, La Conception, University Hospital of Marseille, Marseille.
²¹ Department of Hematology, Saint Eloi hospital, Montpellier University Hospital, Montpellier.
²² Department of Haematology, Sheffield Children's Hospital, Sheffield.
²³ Pediatric Hematology and Oncology, Hannover Medical School, Hannover.
²⁴ Department of Pediatric Oncology/Hematology, Charité Universitätsmedizin, Berlin.
²⁵ Pediatric Oncology, University Children's Hospital Zurich, Zurich. Jean-Pierre.Bourquin@kispi.uzh.ch.

PMID: 39911115
PMCID: PMC12130763
DOI: 10.3324/haematol.2024.286111

Update on long-term outcomes of a cohort of patients with TCF3::HLF-positive acute lymphoblastic leukemia treated with blinatumomab and stem cell transplantation

Aida Zeckanovic et al. Haematologica. 2025.

. 2025 Jun 1;110(6):1373-1378.

doi: 10.3324/haematol.2024.286111. Epub 2025 Feb 6.

Authors

Affiliations

¹ Pediatric Oncology, University Children's Hospital Zurich, Zurich.
² The Kaiya Foundation for Children with Very High Risk Leukemia, London.
³ Department of Pediatric Haemato-Oncology, IRCCS Ospedale Bambino Gesù, Roma, Catholic University of the Sacred Heart, Rome.
⁴ Department of Haematology, Great Ormond Street Hospital, London.
⁵ Department of Pediatric Hematology, Hôpital Robert Debré, Assistance Publique-Hôpitaux de Paris, Paris.
⁶ Department of Pediatrics I, ALL-BFM Study Group, Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein, Kiel.
⁷ Pediatric Hematology-Oncology, Schneider Children's Medical Center, Sackler Faculty of Medicine, Aviv University.
⁸ Department of Pediatric Oncology, Memorial Health Care, Private Medstar Yildiz Hospital, Antalya.
⁹ Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Heidelberg.
¹⁰ Bone Marrow Transplant Unit, Schneider Children's Medical Center, Sackler Faculty of Medicine, Aviv University.
¹¹ Department of Pediatric Hematology, Medipol University Hospital, İstanbul.
¹² Department of Pediatric Hematology and Oncology, Oslo University Hospital, Oslo.
¹³ Department of Paediatric Haematology and Oncology, St. Olav's University Hospital, Trondheim.
¹⁴ University College London Hospitals NHS Foundation Trust, London.
¹⁵ Laboratory of Cytogenetics and Molecular Genetics, ALL-BFM Study Group, Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein, Kiel.
¹⁶ School of Clinical Medicine, UNSW Sydney, Sydney, NSW, Australia; Kids Cancer Centre, Sydney Children's Hospital, Randwick, NSW 2031.
¹⁷ Clinic for Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf.
¹⁸ Adolescent and Young Adult Hematology Unit, Saint Louis University Hospital, Assistance Publique-Hôpitaux de Paris, Paris.
¹⁹ Hematology Laboratory, Saint Louis University Hospital, Assistance Publique-Hôpitaux de Paris, Paris.
²⁰ Hematology and Cellular Therapy Department, La Conception, University Hospital of Marseille, Marseille.
²¹ Department of Hematology, Saint Eloi hospital, Montpellier University Hospital, Montpellier.
²² Department of Haematology, Sheffield Children's Hospital, Sheffield.
²³ Pediatric Hematology and Oncology, Hannover Medical School, Hannover.
²⁴ Department of Pediatric Oncology/Hematology, Charité Universitätsmedizin, Berlin.
²⁵ Pediatric Oncology, University Children's Hospital Zurich, Zurich. Jean-Pierre.Bourquin@kispi.uzh.ch.

PMID: 39911115
PMCID: PMC12130763
DOI: 10.3324/haematol.2024.286111

No abstract available

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Figures

**Figure 1.**
**Swimmer’s plot depicting the disease course of patients with *TCF3::HLF*-positive B-acute lymphoblastic leukemia.** MRD: minimal residual disease; HSCT: hematopoietic stem cell transplantation; CAR T cell: chimeric antibody T cell.

See this image and copyright information in PMC

References

1. Raimondi S, Privitera E, Williams D, et al. . New recurring chromosomal translocations in childhood acute lymphoblastic leukemia. Blood. 1991;77(9):2016-2022. - PubMed
1. Chen X, Wang F, Zhang Y, et al. . Clinical and molecular characteristics of TCF3-Hlf gene fusion-positive B-cell precursor acute lymphoblastic leukemia: a series of 24 cases from a large cohort of leukemia patients. Blood. 2021;138(Suppl 1):2387.
1. Minson KA, Prasad P, Vear S, et al. . t(17;19) in children with acute lymphocytic leukemia: a report of 3 cases and a review of the literature. Case Rep Hematol. 2013;2013:563291. - PMC - PubMed
1. Fischer U, Forster M, Rinaldi A, et al. . Genomics and drug profiling of fatal TCF3-HLF-positive acute lymphoblastic leukemia identifies recurrent mutation patterns and therapeutic options. Nat Genet. 2015;47(9):1020-1029. - PMC - PubMed
1. Watanabe AA-O, Inukai TA-O, Kagami K, et al. . Resistance of t(17;19)-acute lymphoblastic leukemia cell lines to multiagents in induction therapy. Cancer Med. 2019;8(11):5274-5288. - PMC - PubMed

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Update on long-term outcomes of a cohort of patients with TCF3::HLF-positive acute lymphoblastic leukemia treated with blinatumomab and stem cell transplantation

Affiliations

Update on long-term outcomes of a cohort of patients with TCF3::HLF-positive acute lymphoblastic leukemia treated with blinatumomab and stem cell transplantation

Authors

Affiliations

Figures

References

LinkOut - more resources

Full Text Sources