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. 2025 Jun;22(6):e202500140.
doi: 10.1002/cbdv.202500140. Epub 2025 Feb 6.

New Polyketides From Trichoderma harzianum and Their Antifungal Activity

Chengzeng Zhou  1 , Jiayu Pan  1 , Yichao Ge  1 , Xiaodan Wu  2 , Bin Wu  1
Affiliations

New Polyketides From Trichoderma harzianum and Their Antifungal Activity

Chengzeng Zhou et al. Chem Biodivers. 2025 Jun.

Abstract

Chemical investigation of the marine-derived fungus Trichoderma harzianum ZN-4 led to the isolation and identification of seven new secondary metabolites, harzianolides K-Q (1-7). The complete structures of seven new compounds were determined by high-resolution mass spectrometry and nuclear magnetic resonance spectroscopic analyses coupled with electronic circular dichroism calculations. The seven isolates were inactive as antibacterial and antitumor agents. However, harzianolides K (1), L (2), M (3) and O (5) exhibited weak to moderate anti-Pestalotiopsis theae activity with minimum inhibitory concentration values at the range of 25-100 µg/mL.

Keywords: Trichoderma harzianum; antifungal activity; secondary metabolites; structural identification.

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