doi: 10.1080/09546634.2025.2452948.
Epub 2025 Feb 6.
Effectiveness, speed of action and safety of brodalumab in elderly psoriasis patients: a multicenter real-world study - IL PSO (Italian Landscape Psoriasis)
D Orsini
1
, D Graceffa
1
, M Burlando
2
3
, A Campanati
4
, E Campione
5
, C Guarneri
6
, A Narcisi
7
, P Pella
8
, P Romita
9
, M Travaglini
10
, L Zichichi
11
, L M H Arancio
12
, G Baggini
13
, R Balestri
14
, L Bianchi
5
, A M G Brunasso
15
, A E Cagni
16
, Giacomo Caldarola
17
18
, G Calianno
9
, A Carpentieri
10
, M Carriero
19
, A Carugno
20
, F Cona
21
, A Costanzo
7
, E Cozzani
2
3
, Giacomo Dal Bello
22
, Giovanni Carlo Lazzaro Danzuso
23
, A Dattola
24
, A Di Tano
6
, F Diotallevi
4
, M Donnarumma
25
, E De Col
26
, M Esposito
27
, C S Fiorella
28
, M Galluzzo
5
, F Graziola
29
, M Licciardello
30
, A Legori
31
, P Malagoli
32
, Federica Mola
33
, G Moretta
34
, A Muracchioli
35
, A Musumeci
36
, M L Musumeci
37
, G Pagnanelli
34
, V Panasiti
38
, E Provenzano
39
, D Rizzo
11
, M Rubatto
40
, Oriele Sarno
41
, D Strippoli
42
, F Vaira
43
, M C Fargnoli
44
Affiliations
Affiliations
- 1 Clinical Dermatology Unit, San Gallicano Dermatological Institute (IRCCS), Rome, Italy.
- 2 Section of Dermatology, Department of Health Sciences (DiSSal), University of Genoa, Genoa, Italy.
- 3 Department of Health Sciences (DiSSal), University of Genoa, Dermatology Unit ‑ IRCCS San Martino University Hospital, Genoa, Italy.
- 4 Dermatological Clinic, Department of Clinical and Molecular Sciences, Polytechnic Marche University, Ancona, Italy.
- 5 Dermatology, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
- 6 Department of Biomedical and Dental Sciences and Morpho Functional Imaging, Section of Dermatology, University of Messina, Messina, Italy.
- 7 Dermatology Unit, IRCCS Humanitas Research Hospital, Rozzano, Italy.
- 8 Dermatology Unit, Ospedale degli Infermi,, Biella, Italy.
- 9 Section of Dermatology and Venereology, Department of Precision and Regenerative Medicine and Ionian Area (DiMePre-J), University of Bari "Aldo Moro,"Bari, Italy.
- 10 U.O.S.D. Dermatologica - Centro per la cura della psoriasi, Ospedale A. Perrino, Brindisi, Italy.
- 11 Dermatology Unit, Ospedale S A Antonio Abate, ASP Trapani, Erice, Italy.
- 12 Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico Milano, ASST Crema, Crema, Italy.
- 13 Outpatient Clinic, Section of Dermatology, ASL AL, Alessandria, Italy.
- 14 Division of Dermatology, Psoriasis Outpatient Service, APSS, Trento, Italy.
- 15 Department of Internal Medicine-Dermatology, Villa Scassi Hospital, Genoa, Italy.
- 16 Unità Operativa Dipartimentale di Dermatologia e Venereologia, IRCCS San Gerardo, Milan, Italy.
- 17 Dermatology Unit, Agostino Gemelli University Polyclinic Foundation, IRCCS, Rome, Italy.
- 18 Section of Dermatology, Department of Translational Medicine and Surgery, Catholic University of the Sacred Heart, Rome, Italy.
- 19 Dermatology Outpatient, ASL Taranto,, Taranto, Italy.
- 20 Dermatology Unit, Department of Medicine and Surgery, University of Insubria, Varese, Italy.
- 21 Umberto I, City Hospital of Enna, Enna, Italy.
- 22 Section of Dermatology, Department of Medicine, ASST di Mantova, Mantova, Italy.
- 23 U.O.S.D Dermatologia, A.O. 'S.Elia' - Caltanissetta, Caltanissetta, Italy.
- 24 Dermatology Unit, Department of Clinical Internal, Anesthesiological and Cardiovascular Science, University of La Sapienza, Rome, Italy.
- 25 Dermatology Unit, "Andrea Tortora" Hospital, ASL Salerno, Pagani, Italy.
- 26 Unit of Dermatology, Civil Hospital of Imperia, Imperia, Italy.
- 27 Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
- 28 Division of Dermatology, "Mons. Dimiccoli" Hospital, Barletta, Italy.
- 29 Dermatologic Clinic, AOU Maggiore della Carità Hospital, Novara, Italy.
- 30 Section of Dermatology, Koelliker Hospital, Turin, Italy.
- 31 UO Dermatologia IRCCS Ospedale Galeazzi, Università degli Studi di Milano, Milan, Italy.
- 32 Department of Dermatology, Dermatology Unit Azienda Ospedaliera San Donato Milanese, Milan, Italy.
- 33 Dermatology Unit, ASST Lariana, Como, Italy.
- 34 Department of Dermatology, Istituto Dermopatico dell'Immacolata IRCCS Roma, Rome, Italy.
- 35 Unit of Dermatology, San Bartolomeo Hospital, La Spezia, Italy.
- 36 UOSD Dermatologia, ARNAS Garibaldi, Catania, Italy.
- 37 UOC Dermatologia, University of Catania, PO "G. Rodolico", AOU Policlinico "G. Rodolico-San Marco", Catania, Italy.
- 38 Fondazione Policlinico Universitario Campus Bio Medico, Rome, Italy.
- 39 Dermatology Unit, Azienda Ospedaliera di Cosenza, Cosenza, Italy.
- 40 Department of Medical Sciences, Section of Dermatology, University of Turin, Turin, Italy.
- 41 Department of Dermatology and Dermosurgery, AOSG San Giuseppe Moscati, Avellino, Italy.
- 42 Dermatology Unit, Manzoni Hospital, ASST-Lecco, Lecco, Italy.
- 43 Unit of Dermatology, IRCCS Ospedale San Raffaele, Milan, Italy.
- 44 Scientific Direction, San Gallicano Dermatological Institute (IRCCS), Rome, Italy.
- PMID: 39914798
- DOI: 10.1080/09546634.2025.2452948
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Effectiveness, speed of action and safety of brodalumab in elderly psoriasis patients: a multicenter real-world study - IL PSO (Italian Landscape Psoriasis)
D Orsini et al.
J Dermatolog Treat.
2025 Dec.
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doi: 10.1080/09546634.2025.2452948.
Epub 2025 Feb 6.
Authors
D Orsini
1
, D Graceffa
1
, M Burlando
2
3
, A Campanati
4
, E Campione
5
, C Guarneri
6
, A Narcisi
7
, P Pella
8
, P Romita
9
, M Travaglini
10
, L Zichichi
11
, L M H Arancio
12
, G Baggini
13
, R Balestri
14
, L Bianchi
5
, A M G Brunasso
15
, A E Cagni
16
, Giacomo Caldarola
17
18
, G Calianno
9
, A Carpentieri
10
, M Carriero
19
, A Carugno
20
, F Cona
21
, A Costanzo
7
, E Cozzani
2
3
, Giacomo Dal Bello
22
, Giovanni Carlo Lazzaro Danzuso
23
, A Dattola
24
, A Di Tano
6
, F Diotallevi
4
, M Donnarumma
25
, E De Col
26
, M Esposito
27
, C S Fiorella
28
, M Galluzzo
5
, F Graziola
29
, M Licciardello
30
, A Legori
31
, P Malagoli
32
, Federica Mola
33
, G Moretta
34
, A Muracchioli
35
, A Musumeci
36
, M L Musumeci
37
, G Pagnanelli
34
, V Panasiti
38
, E Provenzano
39
, D Rizzo
11
, M Rubatto
40
, Oriele Sarno
41
, D Strippoli
42
, F Vaira
43
, M C Fargnoli
44
Affiliations
- 1 Clinical Dermatology Unit, San Gallicano Dermatological Institute (IRCCS), Rome, Italy.
- 2 Section of Dermatology, Department of Health Sciences (DiSSal), University of Genoa, Genoa, Italy.
- 3 Department of Health Sciences (DiSSal), University of Genoa, Dermatology Unit ‑ IRCCS San Martino University Hospital, Genoa, Italy.
- 4 Dermatological Clinic, Department of Clinical and Molecular Sciences, Polytechnic Marche University, Ancona, Italy.
- 5 Dermatology, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
- 6 Department of Biomedical and Dental Sciences and Morpho Functional Imaging, Section of Dermatology, University of Messina, Messina, Italy.
- 7 Dermatology Unit, IRCCS Humanitas Research Hospital, Rozzano, Italy.
- 8 Dermatology Unit, Ospedale degli Infermi,, Biella, Italy.
- 9 Section of Dermatology and Venereology, Department of Precision and Regenerative Medicine and Ionian Area (DiMePre-J), University of Bari "Aldo Moro,"Bari, Italy.
- 10 U.O.S.D. Dermatologica - Centro per la cura della psoriasi, Ospedale A. Perrino, Brindisi, Italy.
- 11 Dermatology Unit, Ospedale S A Antonio Abate, ASP Trapani, Erice, Italy.
- 12 Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico Milano, ASST Crema, Crema, Italy.
- 13 Outpatient Clinic, Section of Dermatology, ASL AL, Alessandria, Italy.
- 14 Division of Dermatology, Psoriasis Outpatient Service, APSS, Trento, Italy.
- 15 Department of Internal Medicine-Dermatology, Villa Scassi Hospital, Genoa, Italy.
- 16 Unità Operativa Dipartimentale di Dermatologia e Venereologia, IRCCS San Gerardo, Milan, Italy.
- 17 Dermatology Unit, Agostino Gemelli University Polyclinic Foundation, IRCCS, Rome, Italy.
- 18 Section of Dermatology, Department of Translational Medicine and Surgery, Catholic University of the Sacred Heart, Rome, Italy.
- 19 Dermatology Outpatient, ASL Taranto,, Taranto, Italy.
- 20 Dermatology Unit, Department of Medicine and Surgery, University of Insubria, Varese, Italy.
- 21 Umberto I, City Hospital of Enna, Enna, Italy.
- 22 Section of Dermatology, Department of Medicine, ASST di Mantova, Mantova, Italy.
- 23 U.O.S.D Dermatologia, A.O. 'S.Elia' - Caltanissetta, Caltanissetta, Italy.
- 24 Dermatology Unit, Department of Clinical Internal, Anesthesiological and Cardiovascular Science, University of La Sapienza, Rome, Italy.
- 25 Dermatology Unit, "Andrea Tortora" Hospital, ASL Salerno, Pagani, Italy.
- 26 Unit of Dermatology, Civil Hospital of Imperia, Imperia, Italy.
- 27 Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
- 28 Division of Dermatology, "Mons. Dimiccoli" Hospital, Barletta, Italy.
- 29 Dermatologic Clinic, AOU Maggiore della Carità Hospital, Novara, Italy.
- 30 Section of Dermatology, Koelliker Hospital, Turin, Italy.
- 31 UO Dermatologia IRCCS Ospedale Galeazzi, Università degli Studi di Milano, Milan, Italy.
- 32 Department of Dermatology, Dermatology Unit Azienda Ospedaliera San Donato Milanese, Milan, Italy.
- 33 Dermatology Unit, ASST Lariana, Como, Italy.
- 34 Department of Dermatology, Istituto Dermopatico dell'Immacolata IRCCS Roma, Rome, Italy.
- 35 Unit of Dermatology, San Bartolomeo Hospital, La Spezia, Italy.
- 36 UOSD Dermatologia, ARNAS Garibaldi, Catania, Italy.
- 37 UOC Dermatologia, University of Catania, PO "G. Rodolico", AOU Policlinico "G. Rodolico-San Marco", Catania, Italy.
- 38 Fondazione Policlinico Universitario Campus Bio Medico, Rome, Italy.
- 39 Dermatology Unit, Azienda Ospedaliera di Cosenza, Cosenza, Italy.
- 40 Department of Medical Sciences, Section of Dermatology, University of Turin, Turin, Italy.
- 41 Department of Dermatology and Dermosurgery, AOSG San Giuseppe Moscati, Avellino, Italy.
- 42 Dermatology Unit, Manzoni Hospital, ASST-Lecco, Lecco, Italy.
- 43 Unit of Dermatology, IRCCS Ospedale San Raffaele, Milan, Italy.
- 44 Scientific Direction, San Gallicano Dermatological Institute (IRCCS), Rome, Italy.
- PMID: 39914798
- DOI: 10.1080/09546634.2025.2452948
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