Bilirubin Crystals in Neutrophils
- PMID: 39917487
- PMCID: PMC11794724
- DOI: 10.1007/s12288-024-01814-x
Bilirubin Crystals in Neutrophils
Abstract
Neutrophils on peripheral smear provide subtle findings or clues to the diagnosis of haematological disorders. The presence of toxic granules, hypersegmentation, pelgerhuet anamoly, green inclusions provide valuable information for clinicians. One of the rarer inclusions in neutrophils are bilirubin crystals. They are usually seen in children with hyperbilirubunemia and sepsis. We present a case of incidentally detected bilirubin crystals in neutrophils of a three day old child with elevated levels of serum bilirubin. Identification of these crystals should alert the clinician about the possible bilirubin toxicity and poor prognosis.
Keywords: Bilirubin crystals; Neonatal jaundice; Neutrophils; Uncongugated bilirubin.
© Indian Society of Hematology and Blood Transfusion 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
Conflict of interest statement
Conflicts of InterestNot applicable.
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References
-
- Wöll E, Ritter M, Scholz W, Häussinger D, Lang F (1993) The role of calcium in cell shrinkage and intracellular alkalinization by bradykinin in Ha-ras oncogene expressing cells. FEBS Lett 322(3):261–265 - PubMed
-
- Sen Gupta PC, Ghosal SP, Mukherjee AK, Maity TR (1983) Bilirubin crystals in neutrophils of jaundiced neonates and infants. Acta Haematol 70:69–70 - PubMed
-
- Dange P, Desai P, Gupta R, Singh T (2014) Bilirubin crystallization in neutrophils in cases of neonatal unconjugated hyperbilirubinemias. J Appl Hematol 5:117–118