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Review
. 2025 Mar;33(3):1161-1187.
doi: 10.1007/s10787-025-01642-z. Epub 2025 Feb 7.

Atopic dermatitis: a comprehensive updated review of this intriguing disease with futuristic insights

Heidi M Abdel-Mageed  1
Affiliations
Review

Atopic dermatitis: a comprehensive updated review of this intriguing disease with futuristic insights

Heidi M Abdel-Mageed. Inflammopharmacology. 2025 Mar.

Abstract

Atopic dermatitis (AD) is a paradigmatic prevalent, long-lasting, and inflammatory skin condition with a diverse range of clinical manifestations. The etiology and clinical symptoms of AD are influenced by complex pathophysiological processes, which involve a strong genetic component, epidermal dysfunction, and immunological dysregulation, and a strong influence of other physiological and environmental factors. The FDA has approved targeted and well-tolerated immunomodulators including biologics like dupilumab and crisaborole, and small molecules such as baricitinib, as novel therapies for AD. They effectively treat AD but are too expensive for most patients. The review provides an update on the state of knowledge of AD pathogenesis, discusses the available diagnostic and scoring indices, and provides a scientific foundation for treatment methods for AD. This review also presents data on clinical efficacy of innovative treatments' considering recent guidelines, emphasizing the newest medications and ongoing trials. Finally, the new implication of artificial intelligence (AI) in AD management is explored, where AI can speed up diagnosis and therapy. The PubMed, Google Scholar, and ScienceDirect databases were used for this review.

Keywords: Artificial intelligence; Atopic dermatitis; Biological therapy; ChatGPT; Immune dysfunction; JAK inhibitors; Nanodelivery; Skin.

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Conflict of interest statement

Declarations. Conflict of interest: The author declares no competing interests that are relevant to the content of this article. Consent for publication: The manuscript has been approved for publication by the author.

Figures

Figure 1
Figure 1
An outline of atopic dermatitis pathogenesis and mechanism of action of therapeutic agents. Reproduced with permission from Nguyen et al. (2019). CRTH2 chemoattractant receptor homologs molecule expressed on TH2 cells, AhR aryl hydrocarbon receptor, IgE immunoglobulin-E, IL interleukin, and H4R histamine-4 receptor JAK/STAT PDE4 phosphodiesterase 4, R receptor, KOR κ-opioid receptor, NK1R neurokinin-1 receptor, Janus kinase/signal transducer and activator of transcription, and TSLP thymic stromal lymphopoietin
Figure 2
Figure 2
A demonstration of environmental and trigger factors that cause inflammation and the onset and severity of AD clinical course
Figure 3
Figure 3
A diagrammatic representation of AD therapy  based on the severity of the condition
See this image and copyright information in PMC

References

    1. Abędź N, Pawliczak R (2019) Efficacy and safety of topical calcineurin inhibitors for the treatment of atopic dermatitis: meta-analysis of randomized clinical trials. Postepy Dermatol Alergol 36(6):752–759. 10.5114/ada.2019.91425 - PMC - PubMed
    1. Abdel-Mageed HM, AbuelEzz NZ, Radwan RA, Mohamed SA (2021) Nanoparticles in nanomedicine: a comprehensive updated review on current status, challenges and emerging opportunities. J Microencapsul 38:414–436. 10.1080/02652048.2021.1942275 - PubMed
    1. Abdel-Mageed HM, Abd El Aziz AE, Abdel Raouf BM et al (2022a) Antioxidant-biocompatible and stable catalase-based gelatin-alginate hydrogel scaffold with thermal wound healing capability: immobilization and delivery approach. 3Biotech 12:73. 10.1007/s13205-022-03131-4 - PMC - PubMed
    1. Abdel-Mageed HM, Abd El Aziz AE, Mohamed SA, AbuelEzz NZ (2022b) The tiny big world of solid lipid nanoparticles and nanostructured lipid carriers: an updated review. J Microencapsul 39:72–94. 10.1080/02652048.2021.2021307 - PubMed
    1. Abdel-Mageed HM, AbuelEzz NZ, Abdelraouf SM et al (2024) Biomimetic CaCO3 microspheres as a promising delivery system for catalase: Immobilization, kinetic studies and potential perspectives in oxidative stress diseases. Process Biochem 144:324–335. 10.1016/j.procbio.2024.06.010

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