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. 2025 Feb 6;33(2):218-220.
doi: 10.1016/j.str.2025.01.009.

Illuminating cholesterol-mTORC1 signaling: LYCHOS in focus

Hijai R Shin  1 , Roberto Zoncu  2
Affiliations

Illuminating cholesterol-mTORC1 signaling: LYCHOS in focus

Hijai R Shin et al. Structure. .

Abstract

In a recent issue of Nature, Bayly-Jones et al.1 report the first cryoelectron microscopy (cryo-EM) structure of the lysosomal transmembrane protein LYCHOS, which mediates cholesterol sensing by mTORC1. LYCHOS forms a homodimer, with cholesterol engagement at the transporter-GPCR domain interface, coupled to auxin binding at the transporter-like domain, suggesting multi-domain coordination as critical for cholesterol sensing.

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Conflict of interest statement

Declaration of interests R.Z. is co-founder and SAB member of Frontier Medicines and SAB member of Nine Square Therapeutics.

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