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. 1985 Mar;47(3):445-8.

Extracellular distribution of radiolabel obscures specific binding of diethylstilbestrol in mouse skeletal muscle

B Gruber, P M Blix, L Cohen
  • PMID: 3992019

Extracellular distribution of radiolabel obscures specific binding of diethylstilbestrol in mouse skeletal muscle

B Gruber et al. Res Commun Chem Pathol Pharmacol. 1985 Mar.

Abstract

The extracellular distribution of 3H-diethylstilbestrol (3H-DES) in mouse skeletal muscle was assessed following intraperitoneal injection. Total muscle extracellular space was measured with 14C-inulin, and the vascular space with 125I-albumin. A significant difference in the distribution of native 3H-DES and its metabolites in muscle and blood was found. This could only be explained if these compounds distributed with the albumin space and not the inulin space.

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